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Published May 5, 2026
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TAGLN-NeoLib: A falsifiable targeted LC-MS/MS discovery hypothesis for menstrual transgelin neo-fragments in adenomyosis
Authors/Creators
- 1. Independent researcher; Faculty of Medicine, University of Constantine 3 Salah Boubnider, Algeria
Description
TAGLN-NeoLib is an original research hypothesis and targeted biomarker-discovery brief. It proposes to test whether selected transgelin/TAGLN-derived candidate neo-fragments are detectable, reproducible, and relatively enriched in menstrual blood from patients with adenomyosis using targeted LC-MS/MS. The project does not claim a validated diagnostic biomarker and does not propose to measure total TAGLN. The proposed strategy includes clinically relevant comparator groups and strict Go/No-Go rules before any conditional immunoassay development.
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Dates
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2026-05-05Working paper
References
- Dason ES, Maxim M, Sanders A, Papillon-Smith J, Ng D, Chan C, Sobel M. Guideline No. 437: Diagnosis and Management of Adenomyosis. J Obstet Gynaecol Can. 2023;45(6):417-429.e1. doi:10.1016/j.jogc.2023.04.008.
- Ji S, Liu Y, Yan L, Zhang Y, Li Y, Zhu Q, et al. DIA-based analysis of the menstrual blood proteome identifies association between CXCL5 and IL1RN and endometriosis. J Proteomics. 2023;289:104995. doi:10.1016/j.jprot.2023.104995.
- Peterson AC, Russell JD, Bailey DJ, Westphall MS, Coon JJ. Parallel reaction monitoring for high resolution and high mass accuracy quantitative, targeted proteomics. Mol Cell Proteomics. 2012;11(11):1475-1488. doi:10.1074/mcp.O112.020131.
- Rauniyar N. Parallel Reaction Monitoring: A Targeted Experiment Performed Using High Resolution and High Mass Accuracy Mass Spectrometry. Int J Mol Sci. 2015;16(12):28566-28581. doi:10.3390/ijms161226120.
- The UniProt Consortium. UniProtKB: Q01995 — TAGLN, Transgelin, Homo sapiens. UniProt.
- National Center for Biotechnology Information. TAGLN transgelin [Homo sapiens (human)], Gene ID: 6876. NCBI Gene.
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