TAGLN-NeoLib: A falsifiable targeted LC-MS/MS discovery hypothesis for menstrual transgelin neo-fragments in adenomyosis

Chams Eddine ACHI
2026 · doi:10.5281/zenodo.20043691 · W7160445304
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TAGLN-NeoLib proposes testing whether transgelin-derived neo-fragments are detectable and enriched in menstrual blood from adenomyosis patients using targeted LC-MS/MS.

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TAGLN-NeoLib proposes a targeted liquid chromatography-tandem mass spectrometry strategy to detect specific transgelin-derived neo-fragments in menstrual blood. The hypothesis aims to identify reproducible peptide signatures that are relatively enriched in patients with adenomyosis compared to control groups, without measuring total TAGLN levels. The protocol establishes strict go/no-go criteria to validate these candidates before advancing to immunoassay development, explicitly noting that it does not claim to offer a validated diagnostic biomarker at this stage. This paper is centrally about adenomyosis — specifically proposing a novel proteomic method for discovering potential disease-specific biomarkers in menstrual fluid.

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Abstract

TAGLN-NeoLib is an original research hypothesis and targeted biomarker-discovery brief. It proposes to test whether selected transgelin/TAGLN-derived candidate neo-fragments are detectable, reproducible, and relatively enriched in menstrual blood from patients with adenomyosis using targeted LC-MS/MS. The project does not claim a validated diagnostic biomarker and does not propose to measure total TAGLN. The proposed strategy includes clinically relevant comparator groups and strict Go/No-Go rules before any conditional immunoassay development.
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Published May 5, 2026 | Version 1.0 Publication Open TAGLN-NeoLib: A falsifiable targeted LC-MS/MS discovery hypothesis for menstrual transgelin neo-fragments in adenomyosis Authors/Creators - 1. Independent researcher; Faculty of Medicine, University of Constantine 3 Salah Boubnider, Algeria Description TAGLN-NeoLib is an original research hypothesis and targeted biomarker-discovery brief. It proposes to test whether selected transgelin/TAGLN-derived candidate neo-fragments are detectable, reproducible, and relatively enriched in menstrual blood from patients with adenomyosis using targeted LC-MS/MS. The project does not claim a validated diagnostic biomarker and does not propose to measure total TAGLN. The proposed strategy includes clinically relevant comparator groups and strict Go/No-Go rules before any conditional immunoassay development. Files TAGLN-NeoLib_Hypothesis_TargetedDiscoveryProtocol_v1.0_2026-05-05.pdf Files (687.5 kB) | Name | Size | Download all | |---|---|---| | md5:63a44200786bbe1a68299c408e50fab4 | 687.5 kB | Preview Download | Additional details Dates - Other - 2026-05-05Working paper References - Dason ES, Maxim M, Sanders A, Papillon-Smith J, Ng D, Chan C, Sobel M. Guideline No. 437: Diagnosis and Management of Adenomyosis. J Obstet Gynaecol Can. 2023;45(6):417-429.e1. doi:10.1016/j.jogc.2023.04.008. - Ji S, Liu Y, Yan L, Zhang Y, Li Y, Zhu Q, et al. DIA-based analysis of the menstrual blood proteome identifies association between CXCL5 and IL1RN and endometriosis. J Proteomics. 2023;289:104995. doi:10.1016/j.jprot.2023.104995. - Peterson AC, Russell JD, Bailey DJ, Westphall MS, Coon JJ. Parallel reaction monitoring for high resolution and high mass accuracy quantitative, targeted proteomics. Mol Cell Proteomics. 2012;11(11):1475-1488. doi:10.1074/mcp.O112.020131. - Rauniyar N. Parallel Reaction Monitoring: A Targeted Experiment Performed Using High Resolution and High Mass Accuracy Mass Spectrometry. Int J Mol Sci. 2015;16(12):28566-28581. doi:10.3390/ijms161226120. - The UniProt Consortium. UniProtKB: Q01995 — TAGLN, Transgelin, Homo sapiens. UniProt. - National Center for Biotechnology Information. TAGLN transgelin [Homo sapiens (human)], Gene ID: 6876. NCBI Gene.

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