Serum Albumin and C3 Complement Levels in Endometriosis
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This study found significantly increased serum C3 complement levels in endometriosis patients compared to controls, while serum albumin levels showed no significant difference.
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Abstract
OBJECTIVE: To compare the efficacy of albumin and C3 complement as serum marker for the early diagnosis of endometriosis in women of reproductive age. STUDY DESIGN: Cross-sectional comparative study. PLACE AND DURATION OF STUDY: Biochemistry Department, Islamic International Medical College, Rawalpindi, in collaboration with the Gynecology and Obstetrics Department, Pakistan Railways Hospital, Rawalpindi, from March 2017 to February 2018. METHODOLOGY: Forty-four patients with endometriosis and 44 controls of reproductive age group were enrolled for the study. Those having other comorbid systemic or endocrine diseases were excluded from the study. Levels of albumin and C3 complement were measured by using Micro Lab 300 and ELISA, respectively; and the results were compared by using SPSS version 21. groups, respectively (p=0.201). The mean serum C3 levels were 1120.9±265 μg/ml and 2241.0±293 μg/ml in the control and endometriosis patient groups, respectively (p <0.001). RESULTS: The mean serum albumin levels were 4.62±0.88 g/dl and 4.42±0.52 g/dl in the control and endometriosis Conclusion: Serum C3 complement were significantly increased in endometriosis patients but not in controls; whereas, serum albumin levels were not significantly different in endometriosis cases as compared to the controls.
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Cited by (10)
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- Therapeutic targeting of interleukin-17C signaling in carcinogenesis of endometriosis 2025
- Evaluation of serum-based inflammatory and haematological markers in patients with endometriosis: A case-control study 2025
- Creation of a rat model of ovarian endometriosis: a novel and easy approach to simulating chocolate cysts 2025
- Complement and coagulation cascade cross-talk in endometriosis and the potential of Janus Kinase inhibitors-a network meta-analysis 2025
- Spatial Transcriptomic Analysis Identifies Epithelium-Macrophage Crosstalk in Endometriotic Lesions 2024
- Potential shared pathogenic mechanisms between endometriosis and inflammatory bowel disease indicate a strong initial effect of immune factors 2024
- The complement system and endometriosis: what's new? 2023
- Is There a Balance in Oxidative-Antioxidant Status in Blood Serum of Patients with Advanced Endometriosis? 2021
- A cellular and molecular portrait of endometriosis subtypes 2021
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