Research Progress on Pharmacological Effects of Guizhi Fuling Pill

Luyao Yao, Xinchun Xiao
In: Journal of Contemporary Medical Practice · 2024 · vol. 6(8) , pp. 152–155 · doi:10.53469/jcmp.2024.06(08).31 · W4401999257
article OA: hybrid CC0
🔓 Open OA copy Full text JSON View on OpenAlex View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-07-17 ⓘ

Guizhi Fuling Pill, a traditional formula, promotes blood circulation and removes stasis, exhibiting anti-inflammatory, analgesic, anti-tumor, and metabolic regulatory effects in treating various gynecological and other diseases.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by qwen3.7-flash, 2026-09-08 · read from full text ⓘ

This review synthesizes current research on the pharmacological mechanisms and clinical applications of Guizhi Fuling Pill, a traditional Chinese medicine formula known for promoting blood circulation and removing stasis. The authors detail findings from various studies demonstrating the formula's anti-inflammatory, analgesic, and anti-tumor properties, alongside its ability to regulate endocrine and lipid metabolism in conditions ranging from pelvic inflammatory disease to uterine fibroids. While the paper highlights efficacy in managing symptoms and improving hemorheology across multiple pathologies, it notes that much of the supporting evidence derives from animal models or small-scale clinical observations rather than large randomized trials. Relevance to endometriosis: listed as one indication for treatment, with specific references cited regarding its use in relieving pain in endometriosis rats and treating related gynecological diseases.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

Guizhi Fuling Pill is a classic formula from Zhang Zhongjing's "Synopsis of the Golden Chamber". The whole formula has the effects of promoting blood circulation and removing blood stasis. In recent years, Guizhi Fuling Pill has been widely used in clinical practice in China. It can not only treat gynecological diseases such as uterine fibroids, ovarian cysts, polycystic ovary syndrome, endometriosis, pelvic inflammatory disease, and adenomyosis, but also play a positive therapeutic role in diseases such as prostate hyperplasia, coronary heart disease, chronic obstructive pulmonary disease, and hyperlipidemia. Pharmacological studies have confirmed that Guizhi Fuling Pill has anti-inflammatory, analgesic, anti-tumor, blood rheology improving, endocrine and lipid metabolism regulating effects. This article aims to systematically review and elucidate the pharmacological mechanisms and clinical effects of Guizhi Fuling Pills, providing reference for further research and clinical applications.
Full text 5,961 characters · extracted from oa-doi-fallback · click to expand
Research Progress on Pharmacological Effects of Guizhi Fuling Pill DOI: https://doi.org/10.53469/jcmp.2024.06(08).31Keywords: Guizhi Fuling Pill, Clinical application, Pharmacological effects, Research progress, Synopsis of the Golden Chamber, GynaecologyAbstract Guizhi Fuling Pill is a classic formula from Zhang Zhongjing's "Synopsis of the Golden Chamber". The whole formula has the effects of promoting blood circulation and removing blood stasis. In recent years, Guizhi Fuling Pill has been widely used in clinical practice in China. It can not only treat gynecological diseases such as uterine fibroids, ovarian cysts, polycystic ovary syndrome, endometriosis, pelvic inflammatory disease, and adenomyosis, but also play a positive therapeutic role in diseases such as prostate hyperplasia, coronary heart disease, chronic obstructive pulmonary disease, and hyperlipidemia. Pharmacological studies have confirmed that Guizhi Fuling Pill has anti-inflammatory, analgesic, anti-tumor, blood rheology improving, endocrine and lipid metabolism regulating effects. This article aims to systematically review and elucidate the pharmacological mechanisms and clinical effects of Guizhi Fuling Pills, providing reference for further research and clinical applications. References Wu Ruihua, Tao Yuan, Liu E, etc Correlation analysis between serum CRP, Fib levels and the prognosis of Guizhi Fuling Pill in the treatment of pelvic inflammatory masses [J] Clinical Medical Research and Practice, 2023, 8 (25): 21-24. Jiang Li, Jiang Mengjie, Han Ke The effect of Guizhi Fuling Pill on serum inflammatory factor levels and expression of caspase-3 and caspase-8 in uterine tissue of rats with chronic pelvic inflammatory disease [J] Traditional Chinese patent medicines and simple preparations, 2021, 43 (10): 2846-2850. Xie Zhihui, Bao Hongtao, Zhao Fenqin, etc Experimental study on the effect of Guizhi Fuling Pill on MMP-9 expression in uterine and ovarian tissues of pelvic inflammatory disease model rats [J] China Traditional Chinese Medicine Science and Technology, 2018, 25 (5): 638-640. Wang Minjie, Xu Chuanhua Prediction of the mechanism of Guizhi Fuling Pill in treating sequelae of pelvic inflammatory disease based on network pharmacology [J] Medical Information, 2023, 36 (18): 21-26. Chen Yun, Li Zhiqiang, Mao Li, etc The effect of Guizhi Fuling Pill on symptoms, ultrasound and hemorheology in patients with chronic pelvic inflammatory disease of qi stagnation and blood stasis type [J] Guangming Traditional Chinese Medicine, 2019, 34 (9): 1316-1319. Xing Lei, Qu Miaomiao, Zhang Xiaoyun The antitumor effect and mechanism of Guizhi Fuling Pill on transplanted ovarian cancer in rats [J] Western Medicine, 2020, 32 (4): 515-519. Jiang Shihong, Li Lan, Wu Yaosong, etc Guizhi Fuling Pill inhibits the proliferation of human breast cancer cell MCF-7 [J] Chinese Journal of Experimental Pharmacology, 2018, 24 (15): 132-136. Yang Guang, Luo Liping The effect and mechanism of Guizhi Fuling Pill on the biological behavior of cervical cancer cells [J] Sichuan Traditional Chinese Medicine, 2021, 39 (4): 54-57. Wu Xiaoqing, Lu Wenping Exploring the mechanism of Guizhi Fuling Pill in treating ovarian cancer based on network pharmacology and molecular docking [J] Journal of Hainan Medical College, 2021, 27 (19): 1493-1502. Liu Can pattern, Tang Biao The effect of Guizhi Fuling Pill on NF - κ B/COX-2/PGF2 α pathway in uterine tissue of rats with primary dysmenorrhea [J] Journal of Hunan University of Traditional Chinese Medicine, 2022, 42 (6): 873-877. Chen Jiao, Gui Zaizhi, Yan Huaijiang, etc Study on the Effect and Mechanism of Guizhi Fuling Pill in Relieving Pain in Endometriosis Rats [J] Shi Zhen Traditional Chinese Medicine, 2020, 31 (10): 2305-2308. Zheng Shunjie, Hu Min, Hu Meixu, etc The effect of Guizhi Fuling Pill combined with Mifepristone on hemorheology, immune function, serum CA125 and vascular endothelial growth factor-C expression in elderly patients with uterine fibroids [J] Chinese Journal of Gerontology, 2020, 40 (15): 3194-3197. Wang Huabin The therapeutic effect of Guizhi Fuling Pill as an adjuvant therapy for chronic pelvic inflammatory disease and its effects on hemorheology, oxidative stress, serum hs CRP, TGF - β 1, GM-CSF, and complement C3 levels [J] Chinese Journal of Traditional Chinese Medicine, 2020, 38 (2): 214-217. Ye Zhihui, Yin Jiayao, Yang Ying, etc The effect of Guizhi Fuling Pill combined with Mifepristone on hemorheology, hemoglobin, and human epididymal protein 4 in patients with uterine fibroids [J] Advances in Modern Biomedicine, 2020, 20 (9): 1753-1756. Li Feng, Fan Xiangyu, Zheng Fang, etc Research progress on the correlation between vascular endothelial growth factor and traditional Chinese medicine's ability to remove blood stasis and unblock collaterals [J] Chinese Journal of Traditional Chinese Medicine, 2017, 35 (9): 2238-2240. Li Yin, Zhu Hongqiu, Liu Min, etc The effect of Guizhi Fuling Pill on regulating polycystic ovary syndrome model rats through PI3K/Akt/mTOR pathway [J] Shi Zhen Traditional Chinese Medicine, 2020, 31 (11): 2610-2613. You Pingping, Dai Lian, Ke Yuanyuan, etc Effect of Guizhi Fuling Pill combined with western medicine on patients with type 2 diabetes [J] Practical Integrated Traditional Chinese and Western Medicine Clinical Practice, 2021, 21 (14): 20-21+26. Zhao Qiusheng, Tan Xiufen, Wang Nansu The effect of Guizhi Fuling Pill on insulin resistance and adiponectin in polycystic ovary syndrome rats [J] New Traditional Chinese Medicine, 2012, 44 (1): 116-117. Downloads Published How to Cite Issue Section License Copyright (c) 2024 Luyao Yao, Xinchun Xiao This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License. Deprecated: json_decode(): Passing null to parameter #1 ($json) of type string is deprecated in /www/bryanhousepub/ojs/plugins/generic/citations/CitationsPlugin.inc.php on line 49

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: oa-doi-fallback ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Condition tags

endometriosisadenomyosis

Citation neighborhood (no data yet)

We don't have any in-corpus citations linked to this paper yet. This is a recent paper (2024) — citers typically take a year or two to land, and the OpenAlex reference graph may still be filling in.

Source provenance

openalex
last seen: 2026-06-04T00:00:01.174412+00:00
License: CC0 · commercial use OK