The Effect of Follicular-fluid Exposure of Endometriosis Cyst Patients toward the Levels of Bcl-2 and Cytochrome-C in Mice Oocyte

Ida Bagus Putra Adnyana, I Made Jawi, Ketut Suwiyoga, I Made Bakta, I Nyoman Mantik Astawa, M.Med H. Mochamad Anwar, Ida Bagus Putra Manuaba, I Wayan Putu Sutirta Yasa, Bagus Komang Satriyasa
In: Open Access Macedonian Journal of Medical Sciences · 2020 · vol. 8(A) , pp. 567–570 · doi:10.3889/oamjms.2020.4791 · W3091875555
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Exposure of mice oocytes to endometriosis cyst follicular fluid significantly increased Cytochrome C levels, indicating mitochondrial apoptosis, but did not significantly alter Bcl-2 levels.

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Abstract

BACKGROUND: Endometriosis cysts adversely affect a woman’s quality of life, which causes pain and reduces fertility. The World Health Organization found that the incidence of endometriosis with infertility clinical manifestations is around 10%. AIM: The purpose of this study is to determine the presence of mice oocytes mitochondrial apoptosis exposed with endometriosis cysts follicular fluid through Bcl-2 and cytochrome C analysis. METHODS: This study was a randomized post-test only control group design conducted at Sanglah Hospital, Bali Royal Hospital in Denpasar, and the Medical Faculty Udayana University from June 2018 to April 2019. A total of 120 mice oocytes were distributed randomly into three groups, i.e., treatment Groups 1 and 2 that added by 15% endometriosis cysts follicular fluid and control group. Bcl-2 and Cytochrome C analyzed with ELISA Technique. Comparability was tested with one-way ANOVA with a significance level of p < 0.05. RESULTS: Eighteen mice oocyte replicates were normally distributed and homogeneous. The Bcl-2 levels in the treatment Groups 1, and 2 and control were 627.83 ± 146.42, 634.50 ± 140.62, and 678.83 ± 152.71, respectively; p = 0.838 (not significantly different). Cytochrome C levels in the treatment Groups 1, and 2, and control, respectively, were 3147.75 ± 228.50, 3104.45 ± 211.29, and 2738.28 ± 227.45; p = 0.021 (significantly different). CONCLUSION: The effect of endometriosis cysts follicular fluid exposure on mitochondrial apoptosis is proven through Cytochrome C, whereas Bcl-2 is not proven.

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endometriosisinfertility

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