Role of oxidative stress in genesis of endometriosis

Н. Ф. Захаренко, Т. Ф Татарчук, Н. В. Коваленко
In: Reproductive Endocrinology · 2014 · vol. 0(18) , pp. 13 · doi:10.18370/2309-4117.2014.18.13-16 · W2216570603
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⚙ AI-generated summary by claude@2026-06, 2026-06-10 ⓘ

This study found increased lipid peroxidation in women with endometriosis compared to healthy controls, indicating the role of oxidative stress in endometriosis genesis.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-10 ⓘ

This study compared 139 women with endometriosis to 192 healthy controls, analyzing the frequencies of allelic variants in GSTM1, GSTT1, and CYP2D6 genes and assessing lipid peroxidation status as a measure of oxidative stress. The authors found higher lipid peroxidation activity in women with endometriosis than in controls, regardless of the site of endometriotic lesions, and interpret this as evidence for oxidative stress involvement in endometriosis formation. As a caveat, the abstract does not provide details on how lipid peroxidation was measured or on any statistical adjustment for genetic polymorphisms, and the analysis is described at a high level. This paper is centrally about endometriosis — it focuses on oxidative stress and lipid peroxidation as part of endometriosis genesis.

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Abstract

A comparison of frequencies of allelic variants of genes GSTM1, GSTT1, CYP2D6 in women with endometriosis (139 women) and healthy women (192 women in the control group) was made, and the state of lipid peroxidation in women studied groups was study. The results showed that activity of lipid peroxidation higher in women with endometriosis, regardless of the site of endometriotic lesions, compared with the control group of healthy women. This demonstrates the importance of oxidative stress in the endometriosis formation. Also, the results of research suggest that one way of leveling oxidative stress in women with endometriosis can be used of ferric drugs (Maltofer), due to the peculiarities of their digestion and minimize the risk of oxidative stress worsening.

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endometriosis

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