Role of oxidative stress in genesis of endometriosis

Role of oxidative stress in genesis of endometriosis DOI: https://doi.org/10.18370/2309-4117.2014.18.13-16Keywords: endometriosis, oxidative stress, lipid peroxidation, ferric iron, MaltoferAbstract A comparison of frequencies of allelic variants of genes GSTM1, GSTT1, CYP2D6 in women with endometriosis (139 women) and healthy women (192 women in the control group) was made, and the state of lipid peroxidation in women studied groups was study. The results showed that activity of lipid peroxidation higher in women with endometriosis, regardless of the site of endometriotic lesions, compared with the control group of healthy women. This demonstrates the importance of oxidative stress in the endometriosis formation. Also, the results of research suggest that one way of leveling oxidative stress in women with endometriosis can be used of ferric drugs (Maltofer), due to the peculiarities of their digestion and minimize the risk of oxidative stress worsening. References - Ivashchenko T.E., Swed N.Y., Bespalova O.N. et al. «Genetic basis of susceptibility to obstetrical and gynecological pathology.» Molecular Medicine, 3(2007):19-26. - Horovenko N.G., Podolskaya S. «The role of genetically determined changes of detoxification system in the development of pathological conditions.» Collected Works of employees of the NMAPE named after P.L. Shupyk, 19(Book 3) (2010):88-94. - Kramareva N.L. «Role of components of the immune system and genetic factors in the pathogenesis and treatment of external genital endometriosis.» Author’s abstract ... thesis for a PhD. St. Petersburg, (2002): 24 p. - Levkovych N.M., Rossokha S.I., Horovenko N.G. «Analysis of the frequency of allelic variant * 4 gene CУР2D6 in population of Ukraine.» Collected Works of employees of the NMAPE named after P.L. Shupyk, 19(Book 3) (2010):224-234. - Kulinskiy V.I., Kolesnichenko L.S. «Glutathione system I. Synthesis, transpоrt, glutathione, glutathione peroxidase.» Biomedical Chemistry, 55(3) (2009):255-277. - Kurashvili V.A., Maylem L. «New in preventing of the oxidative stress.» Journal of Natural Medicine, 1(2001):91-142. - Nagornaya N.V., Chetverik N.A. «Oxidative stress: effects on the human body, evaluation methods.» Contemporary Pediatrics, 2(2010):89-93. - Arand M., Muhlbauer R., Hengstler J., Jager E., Fuchs J., Winkler L., Oesch F.A. «A Multiplex Polymerase Chain Reaction Protocol for the Simultaneous Analysis of the Glutathione S-Transferase GSTM11 and GSTT1 Polymorphisms.» Analytical Biochemistry, 236(1996):184-186. - Borghese B., Vaiman D., de Ziegler D. et al. «Endometriosis and genetics: what responsibility for the genes?» J. Gynecol. Obstet. Biol. Reprod, 39(3) (2010):196-207 - Fauconnier A., Chapron C., Dubuisson J.B., Vieira M., Dousset B., Breart G. «Relation between pain symptoms and the anatomic location of deep infiltrating endometriosis.», 78(4) (2002):719-726. - Dun E.C., Taylor R.N., Wieser F. «Advances in the genetics of endometriosis.» Genome Med, 2(10) (2010):75. - Gupta S. et al. «Role of oxidative stress in endometriosis.» Reproduktive BioMedicine Online, 13(1) (2006):126-134. - Garte S., Gaspari L., Alexandrie А.К. et al. «Metabolic gene polymorphism frequencies in control population.» Cancer Epidemiol. Biomarkers Prev, 10(2001):1239-1248. - Geisser P. «Iron Terapy with Special Emphasis on Oxidative Stress.» Dtsch.med.Wschr, 121(1996):1301-1302. - Stefansson H., Geirsson R.T., Steinthorsdottir V. et al. «Genetic factors contribute to the risk of developing endometriosis.» Hum. Reprod, 17(2002):555-559. - Tempfer C.B., Simoni М., Destenaves В., Fauser B.C. «Functional genetic polymorphisms and female reproductive disorders: part II –endometriosis.» Hum Reprod Update, 15(1) (2009):97-118. - Zhou S.F. «Polymorphism of human Cytochrome P450 2D6 and its clinical significance: Part I.» Clin. Pharmacogenet, 48(11) (2009):689-732. Downloads Published How to Cite Issue Section License Copyright (c) 2014 Н. Ф. Захаренко, Т. Ф. Татарчук, Н. В. Коваленко This work is licensed under a Creative Commons Attribution 4.0 International License. Authors who publish with this journal agree to the following terms: - Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. - Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.