Treatment of pulmonary endometriosis with a long-acting GnRH agonist

Seltzer VL, Vicki Seltzer, V L Seltzer, BENJAMIN F, F Benjamin, Fred Benjamin
Obstetrics and gynecology · 1990 · vol. 76(5) , pp. 929–931 · doi:10.1097/00006250-199011000-00049 · PMID:2120647 · W1991216925
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-08 ⓘ

A GnRH agonist successfully treated a patient's symptomatic pulmonary endometriosis after surgical and hormonal therapies failed, leading to complete symptom remission and subsequent pregnancy.

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This case report describes a 28-year-old woman with biopsy-proven symptomatic pleural and pelvic endometriosis who experienced treatment failure following two surgical interventions. While danazol provided symptom relief, it was discontinued due to severe side effects, leading to the administration of the long-acting GnRH agonist leuprolide acetate. The patient achieved complete remission of her chest symptoms and subsequently conceived immediately after stopping the therapy. This paper is centrally about endometriosis — specifically the management of thoracic manifestations known as pulmonary or pleural endometriosis using hormonal suppression.

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Abstract

We report the case of a patient who was successfully treated with a long-acting GnRH agonist for pulmonary endometriosis. This 28-year-old woman had symptomatic pleural endometriosis, documented by biopsies, as well as symptomatic pelvic endometriosis. Two surgical procedures, consisting of excision of pleural endometriotic tissue and partial pleurectomies, failed to relieve her chest symptoms. Little relief was achieved with pseudopregnancy treatment. Satisfactory symptomatic improvement was obtained with danazol, but this medication had to be discontinued because of severe side effects. Trial of a GnRH agonist, leuprolide acetate, achieved complete remission of her chest symptoms; in addition, the patient became pregnant immediately after cessation of therapy. Gonadotropin-releasing hormone agonist therapy may be an important therapeutic alternative for women with pulmonary endometriosis who cannot tolerate danazol treatment and in whom surgical therapy fails to relieve the chest symptoms.
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Treatment of pulmonary endometriosis with a long-acting GnRH agonist - Vicki L. Seltzer - Fred Benjamin We report the case of a patient who was successfully treated with a long-acting GnRH agonist for pulmonary endometriosis. This 28-year-old woman had symptomatic pleural endometriosis, documented by biopsies, as well as symptomatic pelvic endometriosis. Two surgical procedures, consisting of excision of pleural endometriotic tissue and partial pleurectomies, failed to relieve her chest symptoms. Little relief was achieved with pseudopregnancy treatment. Satisfactory symptomatic improvement was obtained with danazol, but this medication had to be discontinued because of severe side effects. Trial of a GnRH agonist, leuprolide acetate, achieved complete remission of her chest symptoms; in addition, the patient became pregnant immediately after cessation of therapy. Gonadotropin-releasing hormone agonist therapy may be an important therapeutic alternative for women with pulmonary endometriosis who cannot tolerate danazol treatment and in whom surgical therapy fails to relieve the chest symptoms.(Obstet Gynecol 76:929, 1990)

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Condition tags

endometriosis

MeSH descriptors

Antineoplastic Agents Endometriosis Gonadotropin-Releasing Hormone Pleural Neoplasms Adult Antineoplastic Agents Danazol Danazol Endometriosis Endometriosis Female Gonadotropin-Releasing Hormone Gonadotropin-Releasing Hormone Humans Leuprolide Pelvic Neoplasms Pelvic Neoplasms Pleural Neoplasms Pleural Neoplasms Pleural Neoplasms

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