Evaluation of socio-economic and immune factors related to endometrial cancer

This study evaluated relationships among endometrial cancer grade and stage, peripheral immune phenotypes (including the Th17:Treg ratio), BMI, and socio-economic factors (income, education, insurance status, rural vs urban residence as collected, and tobacco use) in women scheduled for surgery at a single U.S. institution, comparing women with biopsy-confirmed endometrial cancer to surgical controls. Using questionnaire data and FACS-based immune profiling of peripheral blood, the authors found no significant differences in EC stage or grade by income, education level, insurance type, or tobacco use. They observed a significant pro-inflammatory immune shift in EC patients, with higher Th17:Treg ratios versus controls, and also confirmed higher BMI in EC patients, while Th17:Treg ratios were not correlated with socio-economic variables, BMI, or tumor grade. Major limitations explicitly noted were the small sample size (58 total patients) and single-institution enrollment. Relevance to endometriosis: the paper does not explicitly discuss endometriosis; it was included in the corpus via keyword match in the upstream search index.

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