Intestinal and pelvic endometriosis presenting as a tumor and associated with tamoxifen therapy: Report of a case

Leila R. Hajjar, WooShin Kim, George H. Nolan, Sharon Turner, Usha R. Raju
In: Obstetrics & Gynecology · 1993 · vol. 82(4, Part 2) , pp. 642–644 · doi:10.1097/00006250-199310020-00002 · W4243459019
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A 50-year-old woman developed extensive pelvic and intestinal endometriosis after two years of tamoxifen therapy for breast cancer, suggesting a potential link between the drug and the condition.

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This case report describes a 50-year-old postmenopausal woman who developed extensive tumor-like endometriosis in the pelvis and intestine after receiving two years of adjuvant tamoxifen therapy for breast carcinoma. The authors note that while tamoxifen is primarily used for its antiestrogenic effects, it also possesses estrogenic properties that may contribute to the development of such lesions. Consequently, the patient required extensive surgical intervention to address the pelvic and intestinal disease. This paper is centrally about endometriosis — specifically, the presentation of extensive pelvic and intestinal endometriosis as a tumor associated with tamoxifen therapy.

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Abstract

Background: Tamoxifen has been used in the adjuvant treatment of breast cancer because of its antiestrogenic effects. However, recent reports have shown it to have estrogenic effects as well. The purpose of this report is to describe a potential association between tamoxifen therapy and endometriosis. Case: A 50-year-old postmenopausal woman who had received 2 years of adjuvant tamoxifen therapy for breast carcinoma developed extensive tumor-like endometriosis necessitating extensive pelvic and intestinal surgery. Conclusion: This case report highlights the need for obstetricians and gynecologists to be familiar with the actions of tamoxifen and its potential complications.(Obstet Gynecol 1993;82:642-4)
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Background

Tamoxifen has been used in the adjuvant treatment of breast cancer because of its antiestrogenic effects. However, recent reports have shown it to have estrogenic effects as well. The purpose of this report is to describe a potential association between tamoxifen therapy and endometriosis. Case: A 50-year-old postmenopausal woman who had received 2 years of adjuvant tamoxifen therapy for breast carcinoma developed extensive tumor-like endometriosis necessitating extensive pelvic and intestinal surgery.

Conclusion

This case report highlights the need for obstetricians and gynecologists to be familiar with the actions of tamoxifen and its potential complications.(Obstet Gynecol 1993;82:642-4) Copyright © 1993 The American College of Obstetricians and Gynecologists

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Condition tags

endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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