Androgen, estrogen and progestin binding in cytosols of benign gynecologic tumors and tumor-like lesions

Punnonen R, R. Punnonen, K Pettersson, Pettersson K, Vanharanta R, R Vanharanta, A Lukola, Lukola A
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · 1985 · doi:10.1055/s-2007-1013618 · PMID:4077024
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⚙ AI-generated summary by claude@2026-07, 2026-07-09 ⓘ

This study investigated androgen, estrogen, and progestin binding in benign gynecologic tumors, finding simultaneous androgen and progestin receptors were common, and all three receptors were present in one endometrioma.

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⚙ AI-generated deep summary by claude@2026-07, 2026-07-09 · read from full text ⓘ

The paper investigated binding characteristics of androgens, estrogens, and progestins in cytosols from benign gynecologic tumors and tumor-like lesions, reporting specific dissociation constants for androgen (Kd 0.27±0.06 nM), estrogen (Kd 0.19±0.04 nM), and progestin (Kd 0.22±0.07 nM). A common finding was that androgen and progestin receptors were simultaneously present. It also reported that in one endometrioma, specific binding for androgen, estrogen, and progestin was observed simultaneously. This paper is centrally about endometriosis — it includes an endometrioma demonstrating concurrent androgen, estrogen, and progestin binding in cytosol.

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Abstract

Specific androgen (Kd 0.27 +/- 0.06 nM), estrogen (Kd 0.19 +/- 0.04 nM) and progestin (Kd 0.22 +/- 0.07 nM) binding were investigated in benign gynecologic tumors and tumor-like lesions. The simultaneous presence of androgen and progestin receptors was a common finding. In one endometrioma, specific androgen, estrogen and progestin binding was observed simultaneously.
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Subscribe to RSS Please copy the URL and add it into your RSS Feed Reader. https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000025.xml Horm Metab Res 1985; 17(11): 607-609 DOI: 10.1055/s-2007-1013618 DOI: 10.1055/s-2007-1013618 Clinical © Georg Thieme Verlag, Stuttgart · New York Androgen, Estrogen and Progestin Binding in Cytosols of Benign Gynecologic Tumors and Tumor-Like Lesions Further Information Publication History 1983 1984 Publication Date: 14 March 2008 (online) Summary Specific androgen (Kd 0.27±0.06 nM), estrogen (Kd 0.19±0.04 nM) and progestin (Kd 0.22±0.07 nM) binding were investigated in benign gynecologic tumors and tumor-like lesions. The simultaneous presence of androgen and progestin receptors was a common finding. In one endo-metrioma, specific androgen, estrogen and progestin binding was observed simultaneously. Key-Words: Androgen - Estrogen and Progestin Receptors - Gynecologic Tumors

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Condition tags

endometriosisendometrioma

MeSH descriptors

Ovarian Neoplasms Receptors, Androgen Receptors, Estrogen Receptors, Progesterone Adult Aged Cystadenoma Cystadenoma Cytosol Cytosol Dysgerminoma Dysgerminoma Endometriosis Endometriosis Female Humans Middle Aged Ovarian Cysts Ovarian Cysts Ovarian Neoplasms

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europepmc
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pubmed
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