COVID-19 may influence human fertility and sexuality in several ways. Different cell types in gonads show a constitutive expression of angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine subtype 2 (TMPRSS2), which provi…
Pituitary adenomas (PA) and pheochromocytomas/paragangliomas (PHEO/PGL) are rare tumors. Although they may co-exist by coincidence, there is mounting evidence that genes predisposing in PHEO/PGL development, may play a role in pituitary tum…
The objective of the present paper was to assess the presence of hormonal alterations in infertile women with stage I or II endometriosis (Group III, n = 20) compared to fertile women without endometriosis (Group I, n = 14) and to fertile w…
Danazol, a synthetic androgen, is widely used to treat endometriosis and cystic breast disease. We have previously demonstrated that danazol has inhibitory effects on hepatic microsomal cytochrome P450 (P450) system in vitro using several c…
Specific androgen (Kd 0.27 +/- 0.06 nM), estrogen (Kd 0.19 +/- 0.04 nM) and progestin (Kd 0.22 +/- 0.07 nM) binding were investigated in benign gynecologic tumors and tumor-like lesions. The simultaneous presence of androgen and progestin r…
Previous data of lipid and lipoprotein level changes with the application of danazol, an isoxazol derivative of 17-alpha-ethinyl testosterone, have been conflicting. We measured cholesterol, triglycerides, low density lipoproteins and high …