Variations in the Level of Transforming Growth Factor-Alpha (TGFα) mRNA During the Human Menstrual Cycle

R. Stanley Williams, Gregory S. Schultz, Thomas Geoghegan, M. C. Steffan, Marvin A. Yussman
In: Growth Factors and the Ovary · 1989 · pp. 205–208 · doi:10.1007/978-1-4684-5688-2_20 · W935408354
book-chapter OA: closed CC0
Full text JSON View on OpenAlex View at publisher
⚙ AI-generated summary by claude@2026-06+body, 2026-06-11 ⓘ

This study investigates the role of transforming growth factor alpha (TGFα) and its receptor in the human reproductive system by examining its mRNA levels during the menstrual cycle.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by claude@2026-06, 2026-06-11 · read from full text ⓘ

This study examined how transforming growth factor-alpha (TGFα) mRNA levels vary across the human menstrual cycle, motivated by TGFα’s homology to epidermal growth factor (EGF) and shared signaling through the EGF receptor in reproductive physiology. The work assessed TGFα mRNA expression in relation to menstrual-cycle timing, with the key finding that TGFα mRNA levels fluctuate during the cycle. A major limitation is that the provided excerpt contains only the abstract-level context and publication metadata rather than the detailed methods and results, limiting what can be stated about study design specifics and the magnitude of changes. This paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Full text 3,257 characters · extracted from oa-doi-fallback · 3 sections · click to expand

Abstract

Transforming growth factor alpha (TGFα) is a peptide growth factor which is highly homologous to epidermal growth factor (EGF) and shares the epidermal growth factor receptor (EGF-R) to affect its action. These growth factors may play a role in the normal physiology of the human reproductive system. Preview Unable to display preview. Download preview PDF. Similar content being viewed by others

References

Coffey RJ Jr, Derynck R, Wilcox JN, et al. Production and auto-induction of transforming growth factor-α in human keratinocytes. Nature 1987; 328:817–20. Kudlow JE, Kobrin MS, Purchio AF, et al. Ovarian transforming growth factor-a gene expression: immunohistochemical localization to the theca-interstitial cells. Endocrinology 1987:121:1577–9. Williams RS, Schultz GS, Geoghegan TE, Steffan M, Yussman MA. Variations in the transcription of epidermal growth factor (EGF) and EGF-receptor during the human menstrual cycle [Abstract]. Society for Gynecologic Investigation Scientific Program and Abstracts, 35th Annual Meeting Baltimore, March 17–19, 1988; 248. Rall LB, Scott J, Bell GI, et al. Mouse prepro-epidermal growth factor synthesis by the kidney and other tissues. Nature 1985; 313:228–31. Bigsby RM, Cunha GR. Estrogen stimulation of deoxyribonucleic acid synthesis in uterine epithelia cells which lack estrogen receptors. Endocrinology 1986; 119:390–6. Gospodarowicz D III GR, Birdwell CR. Effects of fibroblast and epidermal growth factors on ovarian cell proliferation in vitro. I. Characterization of the response of granulosa cells to FGF and EGF. Endocrinology 1977; 100:108–20. McLachlan JA, DiAugustine RP, Newbold RR. Estrogen induced uterine cell proliferation in organ culture is inhibited by antibodies to epidermal growth factor [Abstract]. 67th Endocrine Society Meeting, 1985; 169. Hofmann GE, Rao CV, Barrows G, Schultz GS, Sanfilippo JS. Binding sites for epidermal growth factor in human uterine tissues and leiomyomas. J Clin Endocrinol Metab 1984:58:880–4. Liu SC, Sanfilippo B, Perroteau I, Erynck R, Salomon DS, Kidwell WR. Expression of transforming growth factor a (TGFα) in differentiated rat mammary tumors: estrogen induction of TGFα production. Mol Endocrinol 1987; 1:683–92. Author information Authors and Affiliations Editor information Editors and Affiliations Rights and permissions Copyright information © 1989 Plenum Press, New York About this chapter Cite this chapter Williams, R.S., Schultz, G.S., Geoghegan, T.E., Steffan, M.C., Yussman, M.A. (1989). Variations in the Level of Transforming Growth Factor-Alpha (TGFα) mRNA During the Human Menstrual Cycle. In: Hirshfield, A.N. (eds) Growth Factors and the Ovary. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5688-2_20 Download citation DOI: https://doi.org/10.1007/978-1-4684-5688-2_20 Publisher Name: Springer, Boston, MA Print ISBN: 978-1-4684-5690-5 Online ISBN: 978-1-4684-5688-2 eBook Packages: Springer Book Archive

Keywords

- Epidermal Growth Factor Receptor - Epidermal Growth Factor - Granulosa Cell - Female Reproductive Tract - Transform Growth Factor Alpha These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: oa-doi-fallback ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Citation neighborhood (no data yet)

We don't have any in-corpus citations linked to this paper yet. The paper's references may be in our DB but unresolved to ``paper_id`` (resolution happens at ingest when the cited DOI matches a row we already have). Run the cross-source citation reconcile pass to retry.

References (8)

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
License: CC0 · commercial use OK