{"paper_id":"efa78c4d-2c4e-4f9f-a106-527a9b275639","body_text":"Abstract\nTransforming growth factor alpha (TGFα) is a peptide growth factor which is highly homologous to epidermal growth factor (EGF) and shares the epidermal growth factor receptor (EGF-R) to affect its action. These growth factors may play a role in the normal physiology of the human reproductive system.\nPreview\nUnable to display preview. Download preview PDF.\nSimilar content being viewed by others\nReferences\nCoffey RJ Jr, Derynck R, Wilcox JN, et al. Production and auto-induction of transforming growth factor-α in human keratinocytes. Nature 1987; 328:817–20.\nKudlow JE, Kobrin MS, Purchio AF, et al. Ovarian transforming growth factor-a gene expression: immunohistochemical localization to the theca-interstitial cells. Endocrinology 1987:121:1577–9.\nWilliams RS, Schultz GS, Geoghegan TE, Steffan M, Yussman MA. Variations in the transcription of epidermal growth factor (EGF) and EGF-receptor during the human menstrual cycle [Abstract]. Society for Gynecologic Investigation Scientific Program and Abstracts, 35th Annual Meeting Baltimore, March 17–19, 1988; 248.\nRall LB, Scott J, Bell GI, et al. Mouse prepro-epidermal growth factor synthesis by the kidney and other tissues. Nature 1985; 313:228–31.\nBigsby RM, Cunha GR. Estrogen stimulation of deoxyribonucleic acid synthesis in uterine epithelia cells which lack estrogen receptors. Endocrinology 1986; 119:390–6.\nGospodarowicz D III GR, Birdwell CR. Effects of fibroblast and epidermal growth factors on ovarian cell proliferation in vitro. I. Characterization of the response of granulosa cells to FGF and EGF. Endocrinology 1977; 100:108–20.\nMcLachlan JA, DiAugustine RP, Newbold RR. Estrogen induced uterine cell proliferation in organ culture is inhibited by antibodies to epidermal growth factor [Abstract]. 67th Endocrine Society Meeting, 1985; 169.\nHofmann GE, Rao CV, Barrows G, Schultz GS, Sanfilippo JS. Binding sites for epidermal growth factor in human uterine tissues and leiomyomas. J Clin Endocrinol Metab 1984:58:880–4.\nLiu SC, Sanfilippo B, Perroteau I, Erynck R, Salomon DS, Kidwell WR. Expression of transforming growth factor a (TGFα) in differentiated rat mammary tumors: estrogen induction of TGFα production. Mol Endocrinol 1987; 1:683–92.\nAuthor information\nAuthors and Affiliations\nEditor information\nEditors and Affiliations\nRights and permissions\nCopyright information\n© 1989 Plenum Press, New York\nAbout this chapter\nCite this chapter\nWilliams, R.S., Schultz, G.S., Geoghegan, T.E., Steffan, M.C., Yussman, M.A. (1989). Variations in the Level of Transforming Growth Factor-Alpha (TGFα) mRNA During the Human Menstrual Cycle. In: Hirshfield, A.N. (eds) Growth Factors and the Ovary. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5688-2_20\nDownload citation\nDOI: https://doi.org/10.1007/978-1-4684-5688-2_20\nPublisher Name: Springer, Boston, MA\nPrint ISBN: 978-1-4684-5690-5\nOnline ISBN: 978-1-4684-5688-2\neBook Packages: Springer Book Archive\nKeywords\n- Epidermal Growth Factor Receptor\n- Epidermal Growth Factor\n- Granulosa Cell\n- Female Reproductive Tract\n- Transform Growth Factor Alpha\nThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.","source_license":"CC0","license_restricted":false}