STUDY ON DETERMINANTS OF SUCCESSFUL OUTCOME IN ICSI PREGNANCIES IN A TERTIARY CARE CENTRE

Devika Vijayan, Prema Nalligounder, Reji Mohan, Sheila Balakrishnan
In: Asian Journal of Pharmaceutical and Clinical Research · 2024 · pp. 82–84 · doi:10.22159/ajpcr.2024.v17i1.48377 · W4390840515
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This descriptive study analyzed 60 patients undergoing intracytoplasmic sperm injection at a tertiary care center to identify factors influencing successful pregnancy outcomes. The results indicated that younger maternal age, female factor infertility, the use of GnRH antagonist stimulation protocols, and frozen embryo transfers were significant determinants of success. While the cohort included patients with various histories, nearly half had undergone prior surgeries such as laparoscopy for endometriosis or polycystic ovarian drilling. Relevance to endometriosis: listed as one indication for prior surgical intervention in the patient cohort, though the paper's main focus is on general ICSI pregnancy outcomes rather than the disease pathology itself.

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Abstract

Objectives: A descriptive study was done at the government medical college in Thiruvananthapuram to find out the determinants of the successful outcome of intracytoplasmic sperm injection (ICSI) pregnancies. Methods: The study was done on 60 ART-conceived patients who underwent ICSI and became positive for pregnancy during 1 year. Their pregnancy was followed up, and data was collected in a structured proforma about determinants of successful outcomes. Results: Out of 60 in vitro fertilization (IVF)-conceived subjects (n=60), the maximum age group (40%) that underwent IVF treatment was between 31 and 35 years old, and they belonged to an upper-lower socio-economic status. 45% of patients had a normal body mass index, 46.7% were overweight, and 8.3% were obese. 73.3% were nulliparas.78.3% had primary infertility, and 21.1% had secondary infertility. The prevalence of male infertility was 6.7%, and female infertility was 81.7%. 81.1% had regular menstrual cycles. 8.3% of patients had medical disorders, and 48% of patients had previous surgeries like polypectomy, polycystic ovarian drilling, and laparoscopy for endometriosis. 71.7% were given the GnRH antagonist stimulation protocol for 8–12 days, and 11–15 eggs were obtained in 66.7% of the patients. 91.7% of frozen embryos were transferred. Conclusion: The success of an ICSI pregnancy is determined by the younger age of the female partner, female factor infertility, antagonist stimulation protocol, and the transfer of a frozen embryo.
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Objectives

A descriptive study was done at the government medical college in Thiruvananthapuram to find out the determinants of the successful outcome of intracytoplasmic sperm injection (ICSI) pregnancies.

Methods

The study was done on 60 ART-conceived patients who underwent ICSI and became positive for pregnancy during 1 year. Their pregnancy was followed up, and data was collected in a structured proforma about determinants of successful outcomes.

Results

Out of 60 in vitro fertilization (IVF)-conceived subjects (n=60), the maximum age group (40%) that underwent IVF treatment was between 31 and 35 years old, and they belonged to an upper-lower socio-economic status. 45% of patients had a normal body mass index, 46.7% were overweight, and 8.3% were obese. 73.3% were nulliparas.78.3% had primary infertility, and 21.1% had secondary infertility. The prevalence of male infertility was 6.7%, and female infertility was 81.7%. 81.1% had regular menstrual cycles. 8.3% of patients had medical disorders, and 48% of patients had previous surgeries like polypectomy, polycystic ovarian drilling, and laparoscopy for endometriosis. 71.7% were given the GnRH antagonist stimulation protocol for 8–12 days, and 11–15 eggs were obtained in 66.7% of the patients. 91.7% of frozen embryos were transferred.

Conclusion

The success of an ICSI pregnancy is determined by the younger age of the female partner, female factor infertility, antagonist stimulation protocol, and the transfer of a frozen embryo. Downloads

References

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