{"paper_id":"ef5d6c00-ca52-4078-a722-e5153890a116","body_text":"STUDY ON DETERMINANTS OF SUCCESSFUL OUTCOME IN ICSI PREGNANCIES IN A TERTIARY CARE CENTRE\nDOI:\nhttps://doi.org/10.22159/ajpcr.2024.v17i1.48377Keywords:\nAge, BMI, female factor infertility, fresh embryo transfer, ICSI.Abstract\nObjectives: A descriptive study was done at the government medical college in Thiruvananthapuram to find out the determinants of the successful outcome of intracytoplasmic sperm injection (ICSI) pregnancies.\nMethods: The study was done on 60 ART-conceived patients who underwent ICSI and became positive for pregnancy during 1 year. Their pregnancy was followed up, and data was collected in a structured proforma about determinants of successful outcomes.\nResults: Out of 60 in vitro fertilization (IVF)-conceived subjects (n=60), the maximum age group (40%) that underwent IVF treatment was between 31 and 35 years old, and they belonged to an upper-lower socio-economic status. 45% of patients had a normal body mass index, 46.7% were overweight, and 8.3% were obese. 73.3% were nulliparas.78.3% had primary infertility, and 21.1% had secondary infertility. The prevalence of male infertility was 6.7%, and female infertility was 81.7%. 81.1% had regular menstrual cycles. 8.3% of patients had medical disorders, and 48% of patients had previous surgeries like polypectomy, polycystic ovarian drilling, and laparoscopy for endometriosis. 71.7% were given the GnRH antagonist stimulation protocol for 8–12 days, and 11–15 eggs were obtained in 66.7% of the patients. 91.7% of frozen embryos were transferred.\nConclusion: The success of an ICSI pregnancy is determined by the younger age of the female partner, female factor infertility, antagonist stimulation protocol, and the transfer of a frozen embryo.\nDownloads\nReferences\nThe Burden of Infertility: Global Prevalence and Women’s Voices from around the World. Boston: Maternal Health Task Force; 2017.\nWHO Global Prevalence of Infertility, Infecundity and Childlessness. Switzerland: WHO; 2019.\nMasoumi SZ, Parsa P, Darvish N, Mokhtari S, Yavangi M, Roshanaei G. An epidemiologic survey on the causes of infertility in patients referred to infertility center in Fatemieh Hospital in Hamadan. Iran J Reprod Med 2015;13:513-6. PMID 26568755\nBroughton DE, Moley KH. Obesity and female infertility: Potential mediators of obesity’s impact. Fertil Steril 2017;107:840-7. doi: 10.1016/j.fertnstert.2017.01.017, PMID 28292619\nSzamatowicz M, Grochowski D. Fertility and infertility in aging women. Gynecol Endocrinol 1998;12:407-13. doi: 10.3109/09513599809012843, PMID 10065166\nKrausz C. Male infertility: Pathogenesis and clinical diagnosis. Best Pract Res Clin Endocrinol Metab 2011;25:271-85. doi: 10.1016/j. beem.2010.08.006, PMID 21397198\nJain K, Radhakrishnan G, Agrawal P. Infertility and psychosexual disorders: Relationship in infertile couples. Indian J Med Sci 2000;54:1-7. PMID 11214514\nKrausz C, Riera-Escamilla A. Genetics of male infertility. Nat Rev Urol 2018;15:369-84. doi: 10.1038/s41585-018-0003-3, PMID 29622783\nTournaye H. Evidence-based management of male subfertility. Curr Opin Obstet Gynecol 2006;18:253-9. doi: 10.1097/01. gco.0000192994.37965.c6, PMID 16735823\nCheung LP, Lam PM, Lok IH, Chiu TT, Yeung SY, Tjer CC, et al. GnRH antagonist versus long GnRH agonist protocol in poor responders undergoing IVF: A randomized controlled trial. Hum Reprod 2005;20:616-21. doi: 10.1093/humrep/deh668, PMID 15608037\nLudwig M, Diedrich K. Evaluation of an optimal luteal phase support protocol in IVF. Acta Obstet Gynecol Scand 2001;80:452-66. doi: 10.1034/j.1600-0412.2001.080005452.x, PMID 11328224\nMaheshwari A, Pandey S, Shetty A, Hamilton M, Bhattacharya S. Obstetric and perinatal outcomes in singleton pregnancies resulting from the transfer of frozen thawed versus fresh embryos generated through in vitro fertilization treatment: A systematic review and meta-analysis. Fertil Steril 2012;98:368-77.e1-9. doi: 10.1016/j. fertnstert.2012.05.019, PMID 22698643\nPublished\nHow to Cite\nIssue\nSection\nCopyright (c) 2023 Devika Vijayan, Prema Nalligounder, Rejimohan, Sheila Balakrishnan\nThis work is licensed under a Creative Commons Attribution 4.0 International License.\nThe publication is licensed under CC By and is open access. Copyright is with author and allowed to retain publishing rights without restrictions.","source_license":"CC0","license_restricted":false}