Endometrial ablation in the treatment of menorrhagia

J. Erian
British journal of obstetrics and gynaecology · 1994 · vol. 101(s11) , pp. 19–22 · doi:10.1111/j.1471-0528.1994.tb13691.x · PMID:8043557 · W2010726694
Non-randomised trial OA: closed CC0 ⤵ 10 in-corpus citations
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This study assessed neodymium yttrium-aluminium-garnet laser ablation for menorrhagia in 2342 women, finding it safe and effective with a 93% satisfactory response rate and few complications.

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Abstract

A prospective 5-year multicentre study, involving three UK gynaecology centres with a special interest in endoscopic laser surgery, was set up to determine the safety, acceptability, clinical effectiveness and complications of neodymium yttrium-aluminium-garnet laser ablation of the endometrium in the treatment of menorrhagia. A total of 2342 women with disabling menorrhagia that was unresponsive to medical therapy were involved. The main outcome measures were: preoperative endometrial preparation; duration of laser ablation, intra- and postoperative complications, amenorrhoea rate, oligomenorrhoea rate, and the women's subjective assessment of treatment. No major complications occurred in the 2342 treatments. Nine (0.4%) cases of transient fluid overload, 11 (0.5%) of infection and five (0.2%) of uterine perforation occurred. None of the women required a laparotomy. The mean duration of the laser ablation was 24 min. The post-surgery amenorrhoea rate was higher in women pretreated with danazol. Of the 1866 women followed up for at least 1 year after treatment, 1043 (56%) developed complete amenorrhoea, 701 (38%) reported continuing but satisfactorily reduced menstruation, and 122 (7%) patients failed to improve with the first treatment (57 of these 122 women responded to a second laser ablation). Overall, 1744 (93%) had a satisfactory response to laser ablation and only 33 (1.8%) required subsequent hysterectomy. In conclusion, this study showed that hysteroscopic endometrial laser ablation is an acceptable alternative to hysterectomy for the treatment of menorrhagia.

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MeSH descriptors

Catheter Ablation Menorrhagia Adolescent Adult Aged Catheter Ablation Endometrium Endometrium Female Humans Laser Therapy Menorrhagia Menstruation Middle Aged Prospective Studies Treatment Failure

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