Intravesical lignocaine in the diagnosis of bladder pain syndrome

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Intravesical lignocaine instillation reduced pain in 68% of women with pelvic pain, aiding in the exclusion of non-bladder origins for their pain.

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This study evaluated whether intravesical instillation of 2% lignocaine could help distinguish pain originating from the urinary bladder versus other pelvic organs in 22 women with pelvic pain, using visual analogue scale (VAS) ratings before and at 2, 10, and 20 minutes after instillation. A 50% reduction in VAS defined responders, who then underwent cystoscopy under anaesthesia; 15 of 22 women (68.18%) were responders, and 13 of these 15 had cystoscopic features suggestive of bladder pain syndrome/interstitial cystitis. Among the seven non-responders, two were diagnosed with endometriosis, four with pelvic inflammatory disease, and one with diverticulitis. The paper relates to endometriosis because endometriosis was specifically identified in two non-responders who did not show pain reduction after intravesical lignocaine, though the study’s main focus is diagnostic exclusion of non-bladder sources of bladder-region pelvic pain.

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Abstract

Introduction and hypothesis To differentiate between the pain originating from urinary bladder and that due to other pelvic organs, using intravesical instillations of 2% lignocaine solution.

Methods

Twenty-two women with pelvic pain received intravesical instillation of 20 ml of 2% lignocaine solution. The intensity of pain was recorded by using visual analogue scale (VAS) just before, at 2, 10 and 20 min after intravesical instillation. Women who experienced a drop in the VAS score by 50% were termed as responders. All these women underwent cystoscopy under anaesthesia.

Results

Fifteen out of 22 (68.18%) women experienced a substantial reduction in the pain. Thirteen out of these 15 women had features suggestive of BPS/IC on cystoscopy. Out of the seven non-responders, two women were found to have endometriosis, four were diagnosed as pelvic inflammatory disease and one had diverticulitis.

Conclusions

Intravesical lignocaine appears to be useful in excluding patients with pelvic pain originating from organs other than the urinary bladder. Similar content being viewed by others Abbreviations - BPS: - Bladder pain syndrome - IC: - Interstitial cystitis - VAS: - Visual analogue scale

References

Parsons CL (2004) Diagnosing chronic pelvic pain of bladder origin. J Reprod Med 49(3 Suppl):235–242 Evans RJ, Stanford EJ (2006) Current issues in the diagnosis of painful bladder syndrome/interstitial cystitis. J Reprod Med 51(3 Suppl):241–252 Asklin B, Cassuto J (1989) Intravesical lidocaine in severe interstitial cystitis. Scand J Urol Nephrol 23(4):311–312 Parsons CL (2005) Successful down regulation of bladder sensory nerves with combination of heparin and alkalinized lidocaine in patients with interstitial cystitis. Urology 65:45–48 Taneja R, Jawade KK (2007) Rational combination of intravesical and systemic agents for the treatment of interstitial cystitis. Scand J Urol Nephrol 41(6):511–515 Ibrahim IA, Diokno AC, Killinger KA et al (2007) Prevalence of self-reported interstitial cystitis (IC) and interstitial-cystitis-like symptoms among adult women in the community. Int Urol Nephrol 39(2):489–495 Kushner L, Moldwin RM (2006) Efficiency of questionnaires used to screen for interstitial cystitis. J Urol 176(2):587–592 Giannakopoulos X, Champilomatos P (1992) Chronic interstitial cystitis: successful treatment with intravesical lidocaine. Arch Ital Urol Nefrol Androl 64:337–339 Seth A, Teichmann JMH (2008) What's new in the diagnosis and management of painful bladder syndrome/interstitial cystitis. Curr Urol Rep 9:349–357 Henry R, Patterson L, Avery N et al (2001) Absorption of alkalized intravesical lidocaine in normal and inflamed bladders: a simple method for improving bladder anesthesia. J Urol 165:1900–1903 Oh SJ, Paick SH, Lim DJ et al (2005) Effects of local anesthetics on human bladder contractility. Neurourol Urodyn 24(3):288–294 Wewers ME, Lowe NK (1990) A critical review of visual analogue scales in the measurement of clinical phenomena. Res Nurs Health 13:227–236

Acknowledgements

I thank Mr. Madan Gopal Chouhan, Ms. Parbati Nayak and Ms. Rajbir Kaur for their cooperation and earnest effort during the course of this study. Conflicts of interest None. Author information Authors and Affiliations Corresponding author Rights and permissions About this article Cite this article Taneja, R. Intravesical lignocaine in the diagnosis of bladder pain syndrome. Int Urogynecol J 21, 321–324 (2010). https://doi.org/10.1007/s00192-009-1045-0 Received: Accepted: Published: Issue date: DOI: https://doi.org/10.1007/s00192-009-1045-0

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MeSH descriptors

Anesthetics, Local Cystitis, Interstitial Lidocaine Administration, Intravesical Adult Cystitis, Interstitial Female Humans Middle Aged Young Adult

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