Analysis code and derived results for: Single-Cell Immune cis-eQTL Mendelian Randomization Prioritizes Cell-Type-Resolved Candidate Causal Genes for Endometriosis

Xin Wang, Guanglei Yao, Wei Ding
2026 · doi:10.5281/zenodo.23273876 · W7221357419
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Corrected analysis code and results for single-cell immune cis-eQTL Mendelian randomization prioritize ten candidate causal genes for endometriosis, providing reproducible genetic prioritization without establishing therapeutic efficacy.

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This repository provides corrected analysis code and derived results for a study utilizing single-cell immune cis-eQTL Mendelian Randomization to prioritize cell-type-resolved candidate causal genes for endometriosis. The revision addresses variant-identity matching, duplicate handling, and multiple-testing power analyses while reanalyzing paired samples from GSE7305. The updated screen encompassed 9,157 unique gene–cell-type tests and identified ten prioritized genes across twenty-eight MR/colocalization pairs. The authors explicitly state that these findings support exploratory genetic prioritization rather than establishing therapeutic efficacy, noting remaining limitations in the reproducibility documentation. This paper is centrally about endometriosis — specifically the use of single-cell genomics to identify potential causal genetic mechanisms underlying the disease.

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Abstract

Corrected R1 release accompanying the revised manuscript submitted to the International Journal of Women's Health (manuscript 643362). This archive contains analysis code, cached inputs, derived result tables, reproducibility instructions and file checksums. The revision corrects variant-identity matching and duplicate handling, recalculates multiple-testing and power analyses, updates complete-window colocalization, and reanalyzes GSE7305 using paired samples. The corrected screen includes 9,157 unique gene–cell-type tests and prioritizes 10 genes across 28 MR/colocalization pairs. These findings support exploratory genetic prioritization and do not establish therapeutic efficacy. The README documents the reproducible analyses, archived ancillary results and remaining limitations.This record provides the corrected R1 analysis code and derived results for manuscript 643362. It supersedes the analysis files in the earlier deposit (https://doi.org/10.5281/zenodo.21234009) for the revised manuscript.
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Analysis code and derived results for: Single-Cell Immune cis-eQTL Mendelian Randomization Prioritizes Cell-Type-Resolved Candidate Causal Genes for Endometriosis Description Corrected R1 release accompanying the revised manuscript submitted to the International Journal of Women's Health (manuscript 643362). This archive contains analysis code, cached inputs, derived result tables, reproducibility instructions and file checksums. The revision corrects variant-identity matching and duplicate handling, recalculates multiple-testing and power analyses, updates complete-window colocalization, and reanalyzes GSE7305 using paired samples. The corrected screen includes 9,157 unique gene–cell-type tests and prioritizes 10 genes across 28 MR/colocalization pairs. These findings support exploratory genetic prioritization and do not establish therapeutic efficacy. The README documents the reproducible analyses, archived ancillary results and remaining limitations. This record provides the corrected R1 analysis code and derived results for manuscript 643362. It supersedes the analysis files in the earlier deposit (https://doi.org/10.5281/zenodo.21234009) for the revised manuscript.

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