in peripheral blood and peritoneal fluid of women with endometriosis - preliminary report

H Tchórzewski
2007 · W2182136157
article OA: closed CC0 Metadata only
View on OpenAlex
⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study found higher CD4+CD25+ cells in peripheral blood but not peritoneal fluid of endometriosis patients, along with decreased IL-10 generation, suggesting a potential role in disease development.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Introduction: CD4 + CD25 + cells play a major role in maintenance of immunological self-tolerance and negative control of pathological and physiological immunological reactions. Their absence or ill function leads to autoimmunization, immunopathology and allergy. The aim of this study was to investigate the prevalence of T lymphocyte subpopulations in peripheral blood and peritoneal fluid of women with endometriosis, as well as IL-10 generation by peripheral blood lymphocytes. Material and methods: The studied group comprised 24 women with endometriosis diagnosed during laparoscopy. The studied group was divided into two parts, depending on progression stage. The control group comprised 12 women without endometriosis. The percentages of subpopulations of T lymphocytes were evaluated via flow cytometry with IMK Plus test (BD Biosciences, USA). IL-10 concentration was analyzed by enzyme-linked immunosorbent assay – ELISA (R&D System, USA). Results: In the present study we observed higher percentage of CD4 + CD25 + cells in peripheral blood of affected women in comparison with healthy subjects. We did not observe such a difference for the peritoneal fluid between the groups. Changes in number of CD4 + CD25 + affect CD8 + shift. We observed a decreased amount of IL-10 in peripheral blood in women with endometriosis. The increase after PHA (phytohaemagglutinin) stimulation was lower in women suffering from endometriosis than in the control group. Conclusions: The quantitative disproportion of CD4 + CD25 + T cells between peripheral blood and peritoneal fluid can affect the onset and development of endometriosis. The impaired migration and function of Treg cells alter composition of peritoneal fluid, which favours the onset and development of endometriosis.

My notes (saved in your browser only)

Condition tags

endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (19)

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
License: CC0 · commercial use OK