Recurrent pregnancy losses, a lasting cause of infertility

de Ziegler D, Dominique de Ziegler, Frydman RF, Rene F Frydman, R Frydman
Fertility and sterility · 2021 · vol. 115(3) , pp. 531–532 · doi:10.1016/j.fertnstert.2020.12.004 · PMID:33581853 · W3127761992
review OA: bronze CC0 ⤵ 2 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-10 ⓘ

This paper examines recurrent pregnancy losses as a significant and persistent cause of infertility in affected individuals.

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Abstract

Recurrent pregnancy loss (RPL), defined as two to three spontaneous pregnancy terminations occurring before 12 weeks of gestation, affects approximately 1% of the general population. The causes may include congenital factors that originate with the quality of the gametes (sperm or oocyte) or the resulting embryo, or factors that originate within the uterus. Alterations of endometrial receptivity from endometriosis and/or endometritis, which are associated with impaired action of progesterone, have also been implicated in RPL. Finally, immunologic factors and thrombophilia, congenital and acquired, have also been suspected to cause RPL.

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Condition tags

infertility

MeSH descriptors

Abortion, Habitual Endometrium Infertility, Female Abortion, Habitual Abortion, Habitual Endometrium Female Humans Infertility, Female Infertility, Female Male Oocytes Oocytes Pregnancy Spermatozoa Spermatozoa Uterus Uterus

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References (4)

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Source provenance

europepmc
last seen: 2026-07-29T06:27:48.050232+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:24:55.077982+00:00
License: CC0 · commercial use OK