Extrapelvic Metastases in Endometrial Stromal Sarcomas: A Clinicopathological Review With Immunohistochemical and Molecular Characterization

Nick Baniak, Adams S, Scott Adams, Cheng-Han Lee, Lee CH, Cheng‐Han Lee, Chibbar R, Rajni Chibbar, Kanthan R, Rani Kanthan
International journal of surgical pathology · 2018 · vol. 27(2) , pp. 208–215 · doi:10.1177/1066896918794278 · PMID:30124116 · W2888377549
review OA: closed CC0 ⤵ 1 in-corpus citation
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This review analyzes the histologic, immunophenotypic, and molecular characteristics of 10 endometrial stromal sarcomas with extrapelvic metastases to understand this rare presentation.

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Abstract

Endometrial stromal sarcoma is a rare uterine tumor associated with favorable outcomes despite its ability to recur and metastasize to distant sites. Most recurrences are local, being limited to the abdomen/pelvis, but distant metastases can occur. Metastatic endometrial stromal sarcoma can occur many months to years after the original diagnosis or may present prior to the primary, potentially creating a diagnostic challenge. We report a bi-institutional review of 10 cases of endometrial stromal sarcoma with extrapelvic metastases without a prior history of endometriosis. The histologic, immunophenotypic, and molecular characteristics of these tumors are analyzed in the context of a relevant literature review.

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Condition tags

endometriosis

MeSH descriptors

Endometrial Neoplasms Sarcoma, Endometrial Stromal Biomarkers, Tumor Biomarkers, Tumor Endometrial Neoplasms Endometrial Neoplasms Female Humans Immunohistochemistry Sarcoma, Endometrial Stromal Sarcoma, Endometrial Stromal

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (43)

Cited by (1)

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License: CC0 · commercial use OK