Extrapelvic Metastases in Endometrial Stromal Sarcomas: A Clinicopathological Review With Immunohistochemical and Molecular Characterization

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AI-generated summary by claude@2026-06, 2026-06-08

This review analyzes the histologic, immunophenotypic, and molecular characteristics of 10 endometrial stromal sarcomas with extrapelvic metastases to understand this rare presentation.

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Abstract

Endometrial stromal sarcoma is a rare uterine tumor associated with favorable outcomes despite its ability to recur and metastasize to distant sites. Most recurrences are local, being limited to the abdomen/pelvis, but distant metastases can occur. Metastatic endometrial stromal sarcoma can occur many months to years after the original diagnosis or may present prior to the primary, potentially creating a diagnostic challenge. We report a bi-institutional review of 10 cases of endometrial stromal sarcoma with extrapelvic metastases without a prior history of endometriosis. The histologic, immunophenotypic, and molecular characteristics of these tumors are analyzed in the context of a relevant literature review.

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Condition tags

endometriosis

MeSH descriptors

Endometrial Neoplasms Sarcoma, Endometrial Stromal Biomarkers, Tumor Biomarkers, Tumor Endometrial Neoplasms Endometrial Neoplasms Female Humans Immunohistochemistry Sarcoma, Endometrial Stromal Sarcoma, Endometrial Stromal

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References (43)

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europepmc
last seen: 2026-06-17T06:13:18.893374+00:00
openalex
last seen: 2026-06-04T00:00:01.174412+00:00
pubmed
last seen: 2026-05-13T22:19:37.156494+00:00
License: CC0 · commercial use OK