Treatment of Chronic Endometritis with the Recruitment of Local Homeostasis and Reproductive Function

This paper evaluated the effectiveness of a complex treatment regimen for infertility associated with morphologically verified chronic endometritis, enrolling 80 reproductive-age women with chronic endometritis and comparing a traditional systemic therapy group (n=30) with an experimental group (n=50) that added local intrauterine and pelvic cavity administration of drugs (including Miramistin, cefazoline/ceftriaxone, Derinat, and alternating with Longidase) followed by 3 months of progesterone. Using multimodal assessments including hysteroscopy with biopsy, histology/immunohistochemistry for endometrial immune markers and ER/PR expression, and ultrasound with Doppler velocimetry, the authors report improved endometrial structure and favorable uterine hemodynamics in all experimental patients, with pregnancy occurring in 46% versus 17% in controls. A key limitation is that the study does not clearly state blinding and uses a small healthy comparison group (n=10) without the same infertility context, which may affect interpretability of outcome differences. This paper is centrally about endometriosis—though it actually studies chronic endometritis therapy and its impact on reproductive function rather than endometriosis, which is not discussed as a primary condition in the provided text.

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