Practical aspects of endometriosis treatment in patients of reproductive age

Objective. To compare the effectiveness of various methods of combined treatment of patients with ovarian endometriosis. Materials and methods. The results of a retrospective study of clinical manifestations and effectiveness of various drugs for the treatment of patients with ovarian endometriosis in the postoperative period are presented in the article. All patients were divided into 4 groups: group I included patients who were treated for endometriosis with dienogest (n = 29), group II consisted of patients who received combined oral contraceptives with gestogen component represented by dienogest (n = 38), patients from group III were administered gonadotropin-releasing hormone agonists (GnRH a) "Buserelin-depot" 1 injection per month for a 6-month course (n = 15); 94 patients from group IV had a history of endometriosis, but did not receive hormone therapy for various reasons. Results. The study revealed more women with fertility disorders in group IV – up to 43.6 ± 10.0 % (p 0.001), primary and secondary infertility lasting up to 4.7 ± 1.2 years was noted. Patients who received hormone therapy had a more realized reproductive history than those who refused treatment for various reasons. Dysmenorrhea incidence was higher in patients who did not receive hormone therapy - up to 24.5 ± 8.7 %, chronic pelvic pains were more frequent in women from group IV (patients who did not receive hormone therapy) as well - up to 83.0 ± 7.6 %. In patients treated for endometriosis with dienogest and GnRH agonists (Buserelin-depot) the longest relapse-free period was noted. Conclusions. The study showed that the results of the medication therapy, carried out for external endometriosis, ovarian endometriosis in particular, in the postoperative period, were different. The use of GnRH agonists and dianogest in postoperative treatment effectively reduced the frequency of endometriosis recurrence in women.