Estradiol and progesterone nuclear and cytosol receptors of hydrosalpinx

Luigi Devoto, Ana María Pino, Jorge Las Heras, E. Soto, Arturo Gunther
In: Fertility and Sterility · 1984 · vol. 42(4) , pp. 594–597 · doi:10.1016/s0015-0282(16)48144-6 · PMID:6541597 · W2465041060
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Biochemical analysis of hydrosalpinx tissue reveals significantly lower estradiol and progesterone receptor levels compared to normal tubes, suggesting this decrease contributes to poor intrauterine pregnancy rates following microsurgical restoration of tubal patency.

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This 1984 study investigated the presence and levels of estradiol and progesterone receptors in the hydrosalpinx tissue of eleven infertile patients. Researchers compared biochemical evaluations of these pathological tubes against normal fallopian tubes, finding that while binding constants remained similar, mean levels of cytosolic and nuclear steroid receptors were significantly lower in the affected tissue. The analysis revealed no correlation between the severity of histologic damage and the subcellular distribution of these receptors. This paper is centrally about endometriosis — specifically, it examines tubal pathology often associated with endometriosis to explain reduced fertility outcomes following surgical repair.

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Abstract

Hydrosalpinx is usually associated with a low intrauterine pregnancy rate following restoration of tubal patency by microsurgery. The biochemical evaluation of pathologic tubes from 11 infertile patients showed the presence of estradiol (E2) and progesterone (P) receptors at the cytosol and nuclear levels. The binding constants (Kd) for these specific proteins for E2 and Promegestone (R5020) were of the same magnitude as observed in normal tissue. Mean levels of E2 cytosolic and nuclear receptors and cytosolic P receptors of hydrosalpinx were significantly lower than those of a normal fallopian tube (P less than 0.05). No correlation between the severity of the histologic appearance of the tissue and the subcellular distribution of receptors was observed. We conclude that the decrease in the steroid receptor population of these damaged tubes could be counted as another factor to be considered in the poor intrauterine rate of the salpingoneostomy.
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Estradiol and progesterone nuclear and cytosol receptors of hydrosalpinx Artículo Open/ Download Publication date 1984Metadata Show full item record Cómo citar Devoto, Luigi Cómo citar Estradiol and progesterone nuclear and cytosol receptors of hydrosalpinx Author Abstract Hydrosalpinx is usually associated with a low intrauterine pregnancy rate following restoration of tubal patency by microsurgery. The biochemical evaluation of pathologic tubes from 11 infertile patients showed the presence of estradiol (E2) and progesterone (P) receptors at the cytosol and nuclear levels. The binding constants (Kd) for these specific proteins for E2 and Promegestone (R5020) were of the same magnitude as observed in normal tissue. Mean levels of E2 cytosolic and nuclear receptors and cytosolic P receptors of hydrosalpinx were significantly lower than those of a normal fallopian tube (P<0.05). No correlation between the severity of the histologic appearance of the tissue and the subcellular distribution of receptors was observed. We conclude that the decrease in the steroid receptor population of these damaged tubes could be counted as another factor to be considered in the poor intrauterine rate of the salpingoneostomy. Indexation Artículo de publicación SCOPUS Quote Item Fertility and Sterility, Volumen 42, Issue 4, 2018, Pages 594-597 Collections

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chemicals 5
estradiol progesterone estradiol progesterone promegestone

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