A mutant single nucleotide polymorphism of follicle-stimulating hormone receptor is associated with a lower risk of endometriosis

Hsin-Shih Wang, Wang HS, Hsin‐Shih Wang, Bi-Hwa Cheng, Cheng BH, Wu HM, Hsien-Ming Wu, Hsien‐Ming Wu, Chih-Feng Yen, Chih‐Feng Yen, Chun‐Ting Liu, Liu CT, Chun-Ting Liu, Chao A, Angel Chao, Tzu-Hao Wang, Wang TH, Tzu‐Hao Wang
Fertility and sterility · 2010 · vol. 95(1) , pp. 455–457 · doi:10.1016/j.fertnstert.2010.07.1092 · PMID:20817169 · W2142851535
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study investigated a specific single nucleotide polymorphism in the follicle-stimulating hormone receptor and found it associated with a reduced risk of developing endometriosis.

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Abstract

Six hundred thirty-seven Taiwanese Chinese women including 300 patients with endometriosis and 337 controls without endometriosis were enrolled to investigate the association between nonsynonymous single nucleotide polymorphism of the FSH receptor gene and the risk of endometriosis. For the A/G polymorphism of FSH receptor gene (Asn680Ser), a univariate analysis for women with endometriosis demonstrated that both the GG genotype (680Ser/Ser) and GA genotype (680Ser/Asn) were associated with a significantly lower risk of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Polymorphism, Single Nucleotide Receptors, FSH Adult Asian People Asian People Asian People Endometriosis Female Genetic Predisposition to Disease Genetic Predisposition to Disease Genotype Humans Middle Aged Receptors, FSH Risk Factors Taiwan Taiwan

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References (14)

Cited by (9)

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