A pilot study of the relationship between selective serotonin reuptake inhibitors and in vitro fertilization outcome

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This retrospective study found no significant differences in IVF outcomes between women taking SSRIs and a matched comparison group, except for a lower ongoing pregnancy rate in the SSRI group.

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Abstract

In a retrospective chart review study women taking selective serotonin reuptake inhibitors antidepressants were compared with a matched comparison group to determine whether there were any differences in IVF outcome-related variables. There were no significant differences between the groups in peak E(2), number of oocytes retrieved, number of oocytes fertilized, percentage of 8-cell or blastocysts developed, day of transfer, or initial hCG values; however, 40% of women taking selective serotonin reuptake inhibitors had ongoing pregnancies compared to 51% of women not taking selective serotonin reuptake inhibitors.

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MeSH descriptors

Fertilization in Vitro Selective Serotonin Reuptake Inhibitors Embryonic Development Embryonic Development Estradiol Estradiol Female Humans Male Oocytes Oocytes Pilot Projects Pregnancy Pregnancy Rate Retrospective Studies Selective Serotonin Reuptake Inhibitors Treatment Outcome

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openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T21:02:47.667321+00:00
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