A pilot study of the relationship between selective serotonin reuptake inhibitors and in vitro fertilization outcome

Susan C. Klock, Sandra Sheinin, Ralph R. Kazer, Xingqi Zhang
In: Fertility and Sterility · 2004 · vol. 82(4) , pp. 968–969 · doi:10.1016/j.fertnstert.2004.02.139 · PMID:15482784 · W2072383317
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This retrospective study found no significant differences in IVF outcomes between women taking SSRIs and a matched comparison group, except for a lower ongoing pregnancy rate in the SSRI group.

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Abstract

In a retrospective chart review study women taking selective serotonin reuptake inhibitors antidepressants were compared with a matched comparison group to determine whether there were any differences in IVF outcome-related variables. There were no significant differences between the groups in peak E(2), number of oocytes retrieved, number of oocytes fertilized, percentage of 8-cell or blastocysts developed, day of transfer, or initial hCG values; however, 40% of women taking selective serotonin reuptake inhibitors had ongoing pregnancies compared to 51% of women not taking selective serotonin reuptake inhibitors.

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