Reproducibility of two different methods for performing mean gray value evaluation of cyst content in endometriomas using VOCAL
This study compared manual and semi-automated virtual organ computer-aided analysis methods for evaluating endometrioma cyst content, finding both reliable but the semi-automated approach faster.
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This study compared two VOCAL-based methods for calculating mean gray value (MGV) of cyst content in 41 histologically confirmed endometriomas: manual sampling of the entire cyst interior versus semi-automated spherical sampling of a 2-cm central sphere, with both observers repeating analyses twice 3 weeks apart to assess intra-observer reproducibility in 20 volumes. There was no statistically significant difference in mean MGV between manual and semi-automated sampling, and the correlation between the two methods was high (r = 0.92). Inter- and intra-observer reproducibility was strong for both approaches based on intra-class correlation coefficients, and the semi-automated method was faster for observer 1. The paper’s main limitation is that reproducibility was assessed in a relatively small volume subset and time comparisons were observer-specific. This paper is centrally about endometriosis—specifically reproducibility of mean gray value measurements of cyst content in ovarian endometriomas using VOCAL.
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