Don't be STUMPed: description and management of uncommon pathologies encountered on specimens from benign gynecologic surgery

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This review describes uncommon benign gynecologic pathologies encountered in surgical specimens, highlighting their diagnostic challenges and management to ensure appropriate treatment.

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Abstract

PURPOSE OF REVIEW: In this review, we aim to describe uncommon pathologies that gynecologic surgeons may reasonably encounter on surgical specimens following benign gynecologic surgery. RECENT FINDINGS: Herein, we describe uncommon pathologic findings of the uterus (e.g. squamous morular metaplasia, fibroid variants, stromal tumor of uncertain malignant potential), peritoneum and adnexa (e.g. endosalpingiosis, serous tubal intraepithelial carcinoma), endometriosis (e.g. stromal endometriosis, atypical endometriosis), and findings of particular interest in postmenopausal women (e.g. ovarian cortical stromal hyperplasia, tubal metaplasia). The majority of pathologic findings presented in this article are inherently benign, although they can present diagnostic challenges. If properly classified, additional treatment and/or extended follow-up is often not required; exceptions are highlighted. SUMMARY: The gynecologic surgeon may encounter uncommon pathologies during a career. Inherent diagnostic difficulties, as well as nonstandardized or outdated terminology, can introduce further uncertainty. Whenever such a situation arises, the surgeon and pathologist should discuss the diagnosis to ensure appropriate treatment options.

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Condition tags

endometriosis

MeSH descriptors

Cystadenocarcinoma, Serous Endometriosis Endometriosis Endometriosis Fallopian Tube Neoplasms Female Gynecologic Surgical Procedures Humans

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europepmc
last seen: 2026-08-12T06:07:16.479679+00:00
pubmed
last seen: 2026-05-13T22:24:31.988741+00:00
unpaywall
last seen: 2026-05-14T19:30:52.867331+00:00
License: public-domain-us · commercial use OK · attribution required
Courtesy of the U.S. National Library of Medicine