Malignant Transformation of Endometriosis: An Unusual Diverticular Mass

S Mohling, Rayan Elkattah, Rachel Eliason, Todd Boren
In: Journal of Endometriosis and Pelvic Pain Disorders · 2016 · vol. 8(2) , pp. 67–70 · doi:10.5301/je.5000239 · W2507622955
Case report OA: closed CC0 ⤵ 2 in-corpus citations
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This case report describes malignant transformation of endometriosis into endometrioid adenocarcinoma of a colonic diverticulum in a patient receiving unopposed estrogen after hysterectomy.

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Abstract

Background Malignant transformation of endometriosis may occur years following hysterectomy and oophorectomy. It may present with a pelvic mass, pain or vaginal bleeding. Risk factors have been poorly defined, but may include exogenous or endogenous unopposed estrogens. Case This report presents a case of malignant transformation of endometriosis resulting in endometrioid adenocarcinoma of a colonic diverticulum in a patient on unopposed estrogen. Conclusions Patients with a history of endometriosis who present with a pelvic mass should be evaluated for the possibility of a tumor arising from the endometriosis, even long after definitive surgical treatment. Sampson's criteria for malignant transformation of endometriosis remain relevant. The continued practice of prescribing unopposed estrogen after hysterectomy to patients with a history of endometriosis may contribute to the frequency of this otherwise uncommon disease.

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endometriosis

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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last seen: 2026-06-10T17:14:06.276822+00:00
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