A case series of four women with clear cell ovarian cancer, with unexpected atypical endometriosis as precursor lesions

Abby Lombardi, Eric Johannesen, Jane A. McElroy, Mark Hunter, Erin Tuller, Albert Hsu, Jean R. Goodman
In: North American Proceedings in Gynecology & Obstetrics · 2024 · vol. 3(2) · doi:10.54053/001c.93948 · W4391915856
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This case series describes four women with clear cell ovarian cancer exhibiting unexpected atypical endometriosis, supporting the hypothesis that this lesion serves as a precursor for these specific rare ovarian carcinomas.

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This case series presents four women diagnosed with clear cell ovarian carcinoma who were found to have coexisting atypical endometriosis acting as precursor lesions. The authors reference historical data from 1925 and subsequent postulations from 1980 that suggest a causative link between endometriosis and rare ovarian carcinomas, particularly clear cell and endometrioid subtypes. By documenting these specific cases, the paper aims to elucidate the evolutionary pathway of cancer subtypes and determine if certain endometriosis variants serve as independent risk factors for malignancy. This paper is centrally about endometriosis — specifically its role as a precancerous lesion leading to clear cell ovarian carcinoma.

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Abstract

Emerging data suggest a causative link between endometriosis and the subsequent development of rare ovarian carcinomas.The coexistence of these two disease processes was first reported in 1925 by John A. Sampson, who described a case in which histological evaluation of a patient's tumor revealed both endometriosis and endometrioid ovarian carcinoma.[1] In 1980, German scientists postulated that endometriosis itself may be a true precancerous lesion, causing certain types of ovarian cancer.Data has since emerged, supporting that endometriosis may be a premalignant lesion in cases of clear cell and endometrioid ovarian carcinomas.We describe four cases of clear cell ovarian carcinoma in the presence of coexisting atypical endometriosis.Documenting such cases is essential to understanding how ovarian cancer and endometriosis may be linked, how specific cancer subtypes may evolve, and whether certain subtypes of endometriosis may be independent risk factors for the development of ovarian cancer.A case series of four women with clear cell ovarian cancer, with unexpected atypical endometriosis as precursor lesions
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North American Proceedings in Gynecology & Obstetrics Special Issue CAOG Conference Abstracts Winter 2022 Emerging data suggest a causative link between endometriosis and the subsequent development of rare ovarian carcino - mas. The coexistence of these two disease processes was first reported in 1925 by John A. Sampson, who described a case in which histological evaluation of a patient’s tumor revealed both endometriosis and endometrioid ovarian carcinoma.[1] In 1980, German scientists postulated that endometriosis itself may be a true precancerous lesion, causing certain types of ovarian cancer. Data has since emerged, supporting that endometriosis may be a premalignant lesion in cases of clear cell and endometrioid ovarian carcinomas. We describe four cases of clear cell ovarian carcinoma in the presence of coexisting atypical endometriosis. Documenting such cases is essential to understanding how ovarian cancer and endometriosis may be linked, how specific cancer subtypes may evolve, and whether certain subtypes of endometriosis may be independent risk factors for the development of ovarian cancer. A case series of four women with clear cell ovarian cancer, with unexpected atypical en- dometriosis as precursor lesions Abstract 1. University of Missouri, Columbia, MO, USA 51CAOG Conference Abstracts Special Issue Abby M. Lombardi, DO , Eric J. Johannesen, DO , Jane A. McElroy, PhD , Mark I. Hunter, MD , Erin R. Tuller, MD , Albert L. Hsu, MD , Jean R. Goodman, MD 1 1 11 1 1 1

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