{"paper_id":"e9d30d9a-f13c-4d3a-b51c-7cadc560c2b3","body_text":"North American Proceedings in\nGynecology & Obstetrics\nSpecial Issue\nCAOG Conference Abstracts\nWinter 2022\nEmerging data suggest a causative link between endometriosis and the subsequent development of rare ovarian carcino -\nmas. The coexistence of these two disease processes was first reported in 1925 by John A. Sampson, who described a case \nin which histological evaluation of a patient’s tumor revealed both endometriosis and endometrioid ovarian carcinoma.[1] \nIn 1980, German scientists postulated that endometriosis itself may be a true precancerous lesion, causing certain types of \novarian cancer. Data has since emerged, supporting that endometriosis may be a premalignant lesion in cases of clear cell \nand endometrioid ovarian carcinomas. We describe four cases of clear cell ovarian carcinoma in the presence of coexisting \natypical endometriosis. Documenting such cases is essential to understanding how ovarian cancer and endometriosis may be \nlinked, how specific cancer subtypes may evolve, and whether certain subtypes of endometriosis may be independent risk \nfactors for the development of ovarian cancer.\nA case series of four women with clear cell \novarian cancer, with unexpected atypical en-\ndometriosis as precursor lesions\nAbstract\n1. University of Missouri, Columbia, MO, USA\n51CAOG Conference Abstracts Special Issue\nAbby M. Lombardi, DO   , Eric J. Johannesen, DO   , Jane A. McElroy, PhD   , Mark I. Hunter, MD   , Erin \nR. Tuller, MD   , Albert L. Hsu, MD   , Jean R. Goodman, MD\n1\n1\n11 1\n1 1","source_license":"CC0","license_restricted":false}