Adenosine Deaminase Family Acting on RNA 1 (ADAR1) May Be a De Novo Target for Endometriosis Treatment

Thuy Ha Vu, Keiichiro Nakamura, Kunitoshi Shigeyasu, Kotaro Kubo, Chiaki Kashino, Hisashi Masuyama
In vivo (Athens, Greece) · 2024 · vol. 38(2) , pp. 683–690 · doi:10.21873/invivo.13489 · PMID:38418109 · PMC10905442 · W4392250799
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⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

This study found significantly higher ADAR1 expression in endometriosis patients and demonstrated that ADAR1 knockdown induces apoptosis in endometriotic cells via specific signaling pathways.

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Abstract

BACKGROUND/AIM: Adenosine deaminase family acting on RNA 1 (ADAR1) expression was examined to determine its correlation with endometriosis. The biological functions and inhibitory effects of ADAR1 knockdown were investigated in a human endometriotic cell line. MATERIALS AND METHODS: ADAR1 was examined in patients with and without endometriosis using reverse transcription polymerase chain reaction (RT-PCR), and the apoptotic expression of ADAR1 small interfering RNA (siRNA) was confirmed using flow cytometry. The biological functions and inhibitory effects of ADAR1 knockdown were investigated using RT-PCR in a 12Z immortalized human endometriotic cell line. RESULTS: ADAR1 expression was significantly higher in patients with endometriosis than in those without (p<0.001). ADAR1 siRNA increased early and late apoptosis, compared to the mock (24.83%) and control (19.96%) cells. ADAR1 knockdown led to apoptosis through MDA5, RIG-I, IRF3, IRF7, caspase 3, caspase 7, and caspase 8 expression in the cell lines. CONCLUSION: ADAR1 is a potential novel therapeutic target in endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Adenosine Deaminase Adenosine Deaminase Adenosine Deaminase Adenosine Deaminase Adenosine Deaminase Adenosine Deaminase Adenosine Deaminase Adenosine Deaminase Adenosine Deaminase Adenosine Deaminase Adenosine Deaminase Adenosine Deaminase Adenosine Deaminase Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis

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References (23)

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europepmc
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