Ambiguedad sexual por exposición a DANAZOL

Oiga Petruc; Mauricio Coll B.; William Onatra H.; Alejandro Giraldo

doi:10.18597/rcog.884

Ambiguedad sexual por exposición a DANAZOL

Oiga Petruc, Mauricio Coll B., William Onatra H., Alejandro Giraldo

In: Revista Colombiana de Obstetricia y Ginecología · 1992 · vol. 43(2) , pp. 147–149 · doi:10.18597/rcog.884 · W2241011314

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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This paper addresses female pseudohermaphroditism, characterized by a XX karyotype and ambiguous external genitalia due to in utero androgen exposure.

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El artículo describe la entidad de pseudohermafroditismo femenino con cariotipo XX, ovarios normales y genitales externos ambiguos con distintos grados de virilización, explicándola como consecuencia de la exposición prenatal a exceso de andrógenos, específicamente danazol. A partir de información del tema y de casos reportados en la literatura, se presenta el mecanismo como una acción androgénica en el feto, incluyendo referencias a efectos adversos del danazol durante el embarazo y a reportes de síndrome de virilización transitoria asociados a esta exposición. Como limitación, el texto se apoya en descripciones de casos y en revisiones/compilaciones más que en un estudio prospectivo o un tamaño muestral amplio con seguimiento estandarizado. Relevancia para endometriosis: el documento no discute endometriosis ni adenomiosis; fue incluido en el corpus de búsqueda de palabras clave que recupera publicaciones con danazol.

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Abstract

Se aplica el término de pseudohermafroditismo femenino a aquellos casos con cariotipo XX, ovarios normales y genitales externos ambiguos por variables grados de virilización que presentan como resultado de exposición a exceso de andrógenos in útero.

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Ambigüedad sexual por exposición a DANAZOL DOI: https://doi.org/10.18597/rcog.884Resumen Se aplica el término de pseudohermafroditismo femenino a aquellos casos con cariotipo XX, ovarios normales y genitales externos ambiguos por variables grados de virilización que presentan como resultado de exposición a exceso de andrógenos in útero. Biografía del autor/a Oiga Petruc Residente III de Pediatría. Departamento de Pediatría. Facultad de Medicina. Universidad Nacional de Colombia. Mauricio Coll B. Profesor Asistente. Departamento de Pediatría. Facultad de Medicina. Universidad Nacional de Colombia. Unidad de Endocrinología Pediátrica. Hospital de la Misericordia. Santafé de Bogotá. D.C. William Onatra H. Profesor Asistente. Departamento de Obstetricia y Ginecología. Facultad de Medicina. Universidad Nacional de Colombia. Instituto Materno Infantil. Santafé de Bogotá. Alejandro Giraldo Jefe Unidad de Genética. Instituto Nacional de Salud . Ministerio de Salud. Referencias bibliográficas Jaffe RB . Disorders of sexual development. Reproductive endocrinology. Yen SC, Jafee RB Edit. W. Saunders Co. 1986. 283-3 12. Zander J , Mickan H, Holzman K. y col. Androluteoma syndrome of pregnancy. Am J Obstet Gynecol. 1978; 130: 170-173. Jones HW JR , Wilkins L. The genital anomaly associated with prenatal exposure to ptogestogens. Fertil Steril 1960; 11 : 148- 150. Peress MR, Kreutner AK, Mathur RS. y col. Female pseudohermaphroditism with somatic chromosomal anomaly in association with in utero exposure to danazol. A m J Obstet Gynecol 1982; 142: 708-709 . Wied GL. (Edit) the current role of danazol in the management of gynecologic disorders: a symposium. J Reprod Med 1990; 35 (supp) 69- 102. Dmowski WP. A synthetic steroid with diverse biologic effects. J reprod med. 1990; 35 (supp) 69-75. Barbieri RL, Lee H, Ryan KJ. Danazol binding to rat androgen glucocorticoid, progesterone and estrogen receptors: correlation with biologic activity. Fertil steril. 1979; 31 : 182- 186. Barbieri RL, Osanthanonfh R. y col. Danazol inhibits human adrenal 21-AND 11 B-hidroxilation in vitro. Steroids 1979; 32: 25 1-263. Shaww RW. Female pseudohermaphroditism associated with danazol exposure in utero. Case report. Br J Obstet Gynecol 1984; 91: 386-389. Colston A. Adverse effects of danazol in pregnancy. Ann intern med 1982; 96: 672-673. Quagliarello J , Alba Greco M. Danazol and urogenital sinus formation in pregnancy . Fertil steril 1985; 43: 939-942. Castro-Magana M, Cheruvanky T. y col. Transient androgenital syndrome dueto exposure to danazol in utero. Am J Dis Child 198 1; 135: 1032- 1034. Courrier R, Jost A. Intersexuality foetal movoquee sar la pregninolone au cours de la grossesse. Cr Soc Biologie 1942; 136: 395-396. Wilkins L, Jones HW. y col. Masculinization of the female fetus associated with administration of oral and intramuscular progestins during gestation: Nonadrenal female pseudohermaphroditism. J Clin Endocrinol Metab. 1958; 18: 558-559. Wong PC, Ratman SS . Masculinization of a female infant exposed to norethisterone during pregnancy. A case report and review of the literature . Syngapure J Obstet Gynecol 1980; 11 : 73-76. Bongiovanni AM, McPadden AJ. Steroids during pregnancy and Possible fetal consequences. Fertil Steril 1960; 11: 181. Jacobson BD. Hazards of norethidione therapy during pregnancy. Am J Obstet Gynecol 1962; 84: 962. Chamness G.C. Asch RH. y col. Danazol binding and translocation of steroid receptor. Am J Obstet Gynecol 1980; 136: 426-429. Duck SC, Katayama KP. Danazol may cause female pseuhermaphroditism. Fertil steril 1981; 35: 230-231. Rosa FW. Virilization of the female fetus with maternal danazol exposure. Am J Obstet Gynecol 1984; 149: 99-100. Money J, Mathews O. Prenatal exposure to virilizing progestins: an adult follow-up study of twelve women. Arch sex behav 1982; 11: 73-83. Cómo citar Descargas Descargas Publicado Número Sección | Estadísticas de artículo | | |---|---| | Vistas de resúmenes | | | Vistas de PDF | | | Descargas de PDF | | | Vistas de HTML | | | Otras vistas |

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References (17)

Adverse Effects of Danazol in Pregnancy via openalex
Danazol and urogenital sinus formation in pregnancy via openalex
Danazol. A synthetic steroid with diverse biologic effects. via openalex
Danazol binding and translocation of steroid receptors via openalex
Danazol Binding to Rat Androgen, Glucocorticoid, Progesterone, and Estrogen Receptors: Correlation With Biologic Activity via openalex
Danazol inhibits human adrenal 21-and 11β-hydroxylation invitro via openalex
Danazol May Cause Female Pseudohermaphroditism via openalex
Female pseudohermaphroditism with somatic chromosomal anomaly in association with in utero exposure to danazol via openalex
Transient Adrenogenital Syndrome due to Exposure to Danazol in Utero via openalex
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[1] Adverse Effects of Danazol in Pregnancy via openalex

[2] Danazol and urogenital sinus formation in pregnancy via openalex

[3] Danazol. A synthetic steroid with diverse biologic effects. via openalex

[4] Danazol binding and translocation of steroid receptors via openalex

[5] Danazol Binding to Rat Androgen, Glucocorticoid, Progesterone, and Estrogen Receptors: Correlation With Biologic Activity via openalex

[6] Danazol inhibits human adrenal 21-and 11β-hydroxylation invitro via openalex

[7] Danazol May Cause Female Pseudohermaphroditism via openalex

[8] Female pseudohermaphroditism with somatic chromosomal anomaly in association with in utero exposure to danazol via openalex

[9] Transient Adrenogenital Syndrome due to Exposure to Danazol in Utero via openalex

[10] doi:10.1016/0002-9378(62)90075-3 via openalex

[11] doi:10.1016/0002-9378(84)90308-9 via openalex

[12] doi:10.1016/s0015-0282(16)33723-2 via openalex

[13] doi:10.1111/j.1471-0528.1984.tb05929.x via openalex

[14] doi:10.1016/0002-9378(78)90362-9 via openalex

[15] doi:10.1007/bf01541367 via openalex

[16] doi:10.1016/s0015-0282(16)33721-9 via openalex

[17] doi:10.1210/jcem-18-6-559 via openalex