Endometriosis and ovarian cancer: clinical and molecular aspects.

Anastasia Pavlidou, A Pavlidou, Pavlidou A, N. F. Vlahos, Nikolaos Vlahos, Vlahos NF
Minerva endocrinologica · 2014 · vol. 39(3) , pp. 155–65 · PMID:25003226 · W2174860900
article OA: closed CC0 ⤵ 9 in-corpus citations
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This review discusses the clinical and molecular links between endometriosis and ovarian cancer, highlighting shared pathophysiological and genetic characteristics, particularly within the PI3K/Akt/mTOR pathway.

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Abstract

Endometriosis is one of the most commonly encountered benign problems in gynecology. Even though endometriosis appears to predispose to ovarian cancer the progression from atypical epithelial proliferation (atypical endometriosis and metaplasia), to the formation of well-defined borderline tumors and finally to endometrioid ovarian cancer will take several years. To elaborate on the concept of endometriosis as a precursor of some types of ovarian cancer, we present an overview of the pathophysiological and genetic characteristics, common in those two conditions. Furthermore, we present the genetic mutations found in ovarian cancers and we outline the common genetic alterations of endometriosis and ovarian cancer, focusing on the PI3K/Akt/mTOR-signaling pathway.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Ovarian Neoplasms Precancerous Conditions Carcinoma Carcinoma Carcinoma, Endometrioid Carcinoma, Endometrioid Cell Transformation, Neoplastic Cell Transformation, Neoplastic Disease Progression Disease Susceptibility Endometriosis Endometriosis Female Genomic Instability Humans Mixed Tumor, Mesodermal Mixed Tumor, Mesodermal Mutation Neoplasm Proteins

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

Cited by (9)

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License: CC0 · commercial use OK