Genetic mechanisms underlying the pathogenesis of tropical calcific pancreatitis

Swapna Mahurkar, Mahurkar S, Reddy DN, D Nageshwar Reddy, G Venkat Rao, Rao GV, Giriraj Ratan Chandak, Chandak GR
World journal of gastroenterology · 2009 · vol. 15(3) , pp. 264–9 · doi:10.3748/wjg.15.264 · PMID:19140225 · PMC2653322
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This review compiles genetic evidence contributing to tropical calcific pancreatitis and proposes a two-hit model to explain the sequence of events in its pathogenesis.

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Abstract

Chronic pancreatitis is known to be a heterogeneous disease with varied etiologies. Tropical calcific pancreatitis (TCP) is a severe form of chronic pancreatitis unique to developing countries. With growing evidence of genetic factors contributing to the pathogenesis of TCP, this review is aimed at compiling the available information in this field. We also propose a two hit model to explain the sequence of events in the pathogenesis of TCP.

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MeSH descriptors

Calcinosis Pancreatitis, Chronic Pancreatitis, Chronic Calcinosis Calcinosis Calcinosis Carrier Proteins Carrier Proteins Genetic Predisposition to Disease Humans Mutation Pancreatitis, Chronic Pancreatitis, Chronic Tropical Climate Trypsin Trypsin Inhibitor, Kazal Pancreatic Trypsinogen Trypsinogen Trypsinogen

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europepmc
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