Endometriosis and IBD: Two Case Reports and Narrative Review of the Literature

Alessia Dalila Guarino, Anna Testa, Olga Maria Nardone, Giuseppe Bifulco, A La Mantia, Pierluigi Giampaolino, Fabiana Castiglione, Miriam Giaquinto, Antonio Rispo, Gastroenterology, T Jess, M Frisch, K Jrgensen, B Pedersen, N Nielsen, N Shigesi, M Kvaskoff, S Kirtley, Q Feng, H Fang, J Knight, . Becker, C, K Karaman, E Pala, U Bayol, O Akman, M Olmez, S Unluoglu, S Ozturk, P Plummer, R Doorgen, B Yglesias, J Phillips, R Doogan, M Craninx, G D'haens, K Cokelaere, F Baert, F Penninckx, A D'hoore, . Geboes, K, A Guadagno, F Grillo, V Vellone, S Ferrero, A Fasoli, R Fiocca, L Mastracci, F Chiaffarino, S Cipriani, E Ricci, E Roncella, P Mauri, F Parazzini, P Vercellini, Z Teke, F Aytekin, A Atalay, N Demirkan, G Popivanov, D Stoyanova, A Fakirova, M Konakchieva, D Stefanov, K Kjossev, V Mutafchiyski, J Torres, S Bonovas, G Doherty, T Kucharzik, J Gisbert, T Raine, . Fiorino, G, F Gomolln, A Dignass, V Annese, H Tilg, G Van Assche, J Lindsay, . Ecco, . Gionchetti, P, M Adamina, A Spinelli, J Warusavitarne, A Armuzzi, O Bachmann, P Bager, L Biancone, B Bokemeyer, P Bossuyt, J Burisch, P Collins, A El-Hussuna, P Ellul, G Fiorino, C Frei-Lanter, F Furfaro, C Gingert, P Gionchetti, F Gomollon, Gonzlez Lorenzo, M Gordon, H Hlavaty, T Juillerat, P Katsanos, K Kopylov, U Krustins, E Kucharzik, T Lytras, T Maaser, C Magro, F Marshall, J Myrelid, P Pellino, G Rosa, I Sabino, J Savarino, E Stassen, L Torres, J Uzzan, M Vavricka, S Verstockt, B Zmora, O, . Doherty, G Kaplan, J Feuerstein, A Cheifetz, H De Souza, C Fiocchi, R Straub, M Cutolo, A Sulli, A Wakefield, A Sawyerr, M Hudson, A Dhillon, R Pounder, M Chen, M Sundrud, K Lee, B Jharap, E Maser, J Colombel, R Yantiss, P Clement, R Young
In: International Internal Medicine Journal · 2023 · vol. 1(4) · doi:10.33140/iimj.01.04.01 · W4386392491
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This paper presents two cases of endometriosis co-occurring with inflammatory bowel disease and reviews literature on their complex differential diagnosis and impact on quality of life.

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Abstract

Endometriosis is a chronic inflammatory disease caused by the presence of ectopic endometrium-like tissue in extrauterine sites (ovaries, uterosacral ligaments, fallopian tubes or peritoneum), affecting up to 10% of young women. Clinical manifestations are heterogeneous, varying from asymptomatic to dysmenorrhea, dyspareunia, infertility or chronic pain. Gastrointestinal (GI) symptoms are reported by patients affected by endometriosis, including abdominal pain, pain during defecation, constipation, diarrhea, nausea, weight loss or obstructive crisis. Inflammatory bowel diseases (IBD) are a group of idiopathic, chronic disease including Crohn’s disease (CD) and ulcerative colitis (UC). Different Authors suggested an association between endometriosis and IBD, reporting different clinical cases, with different scenarios and outcomes. Involvement of GI tract can complicate pelvic endometriosis in 3-37% of cases and the differential diagnosis with inflammatory bowel disease (IBD) represents a challenge for the physicians. Here, we describe two clinical cases of young women affected by IBD associated to endometriosis, underling the importance of differential diagnosis and the impact of these two pathologies on patients’ quality of life.

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Condition tags

endometriosisdysmenorrheadyspareuniainfertility

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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