INFERTILITY, ASSOCIATED WITH ENDOMETRIOSIS, THERAPY: IMMUNOGENOTYPIC PARALELLS

Т. А. Агаркова, K. S. Kublinskiy, I. Evtushenko, И. О. Наследникова, В. Н. Ткачев, V. V. Novitskiy, M. Skorohodova
In: International Journal of Advanced Studies · 2012 · vol. 2(1) · doi:10.12731/2227-930x-2012-1-7 · W1608749561
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Treatment of infertility in women with endometriosis using laparoscopy and hormonal therapy showed low effectiveness in patients carrying risky AA and GA genotypes of the TNFA G-308A polymorphism.

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This study examined 150 patients with infertility associated with genital endometriosis to evaluate the impact of immunogenetic factors on treatment outcomes. The researchers utilized a complex therapeutic approach involving surgical laparoscopy and hormonal agents, including gonadotropin-releasing hormone agonists and combined oral contraceptives. They found that therapy effectiveness was significantly reduced in patients carrying specific risky genotypes, namely the AA and GA polymorphisms of the TNFA gene at position G-308A. This paper is centrally about endometriosis — specifically investigating how genetic polymorphisms influence the success of infertility treatments for patients with this condition.

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Abstract

The clinical and molecular-genetic examinations and therapy of 150 patients, suffering from infertility, with genital endometriosis were carried out by the medical team. The complex treatment included surgical laparoscopic method and hormonal agents (agonists of gonadrophin-releasing-hormones, combined oral contraceptives.) The low effectiveness of the infertility therapy, associated with endometriosis, relates to the carriage of risky genotypes: AA and GA polymorphism G-308A of TNFA gene. DOI: http://dx.doi.org/10.12731/2227-930X-2012-1-7
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INFERTILITY, ASSOCIATED WITH ENDOMETRIOSIS, THERAPY: IMMUNOGENOTYPIC PARALELLS Аннотация The clinical and molecular-genetic examinations and therapy of 150 patients, suffering from infertility, with genital endometriosis were carried out by the medical team. The complex treatment included surgical laparoscopic method and hormonal agents (agonists of gonadrophin-releasing-hormones, combined oral contraceptives.) The low effectiveness of the infertility therapy, associated with endometriosis, relates to the carriage of risky genotypes: AA and GA polymorphism G-308A of TNFA gene. Ключевые слова Полный текст: >PDF (English)Литература Adamyan L.V., Kulakov V.I., Andreeve E.N. Endometriosis. – M., Medicine. 2006.-p.416. Gerasimov A.M. Infertility etiology with external endometriosis// Vestnikakush.gin. – 2008.– №1. – p. 31-35. Krutova V.A., Galustyan S.A., Belkina N.V. Complex therapy of women with infertility, associated with genital endometriosis// Vestnik akush. gin. – 2008. – №2. – p. 46-49. Ischenko A.I., Kudrina E.A. Endometriosis: diagnose and therapy. – М.:МIA. 2008. – p. 176. Simbirtsev A.S., Gromova A.U. Functional genes’ polymorphism of regulatory in flammation molecules // Immunology. – 2005. – №1. – p.67-72. Allaire C. Endometriosis and infertility: a review // J. Reprod. Med. – 2006. – V.51.№3. – Р. 164-168. Campo S., Campo V., Benagiano G. Infertility and adenomyosis // Obstet. Gynecol. Int. – 2012. – V.78.№12. – Р. 956-960. Harada T., Iwabe T., Terakawa N. Role of cytokines in endometriosis // Fertil. Steril. – 2001. – V.76.№1. – Р. 1-10. Iwabe T., Harada T., Terakawa N. Role of cytokines in endometriosis-associated infertility // Gynec. Obstet. Invest. – 2002. – V.53.№1. – Р. 19-25. Senapati S., Barnhart K. Managing endometriosis-associated infertility // Clin. Obstet. Gynecol. – 2011. – V.54.№4. – Р. 720-726. Stilley J.A., Birt J.A., Sharpe-Timms K.L. Cellular and molecular basis for endometriosis-associated infertility // Cell Tissue Res. – 2012. – V.3.№1. – Р. 44-49. Ссылки - На текущий момент ссылки отсутствуют. (c) 2016 International Journal of Advanced Studies Контент доступен под лицензией Creative Commons Attribution-NonCommercial-NoDerivs 4.0. ISSN 2328-1391 (print), ISSN 2227-930X (online)

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endometriosisinfertility

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