Effect of danazol on vocal pitch: a case study

Mercaitis PA, P. A. Mercaitis, Peaper RE, R E Peaper, RE Peaper, Schwartz PA, PA Schwartz, P A Schwartz
Obstetrics and gynecology · 1985 · vol. 65(1) , pp. 131–5 · doi:10.7275/7784 · PMID:3966015 · W403795286
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Acoustic analysis of a woman undergoing danazol therapy for endometriosis revealed a progressive and persistent lowering of vocal pitch that did not fully return to pretreatment levels 12 months after treatment.

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This case study investigates the impact of danazol, a synthetic androgen, on vocal pitch in a single subject. The researchers measured changes in voice characteristics following the administration of the drug to assess potential side effects on the larynx. The findings indicate that danazol treatment can lead to significant lowering of vocal pitch due to its androgenic properties. This paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

Acoustic analysis was used to measure fundamental frequency (vocal pitch in cycles per second) in a woman before, during, and after danazol therapy for endometriosis. A moderate lowering of fundamental frequency occurred within the three months of therapy and progressively lowered throughout the 5.5-month course. There was some action toward pretreatment levels, but 12 months after therapy, lowering of fundamental frequency persisted. The acceptability of this side effect and the need for further research are discussed.
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Log In Email address Password non-UMass log in or Log in with your NetID New non-UMass user? Click here to register. Have you forgotten your password? Home Discover ScholarWorks Statistics Top Items Top Authors Top Subjects Top Countries My Top Items My Top Countries Home School of Public Health and Health Sciences Speech, Language, and Hearing Sciences Communication Disorders Department Faculty Publication Series Effect Of Danazol On Vocal Pitch - A Case-study Publication Effect Of Danazol On Vocal Pitch - A Case-study Mercaitis, PA ; Peaper, RE ; Schwartz, PA Citations Abstract Type article article Date 1985 Publisher Degree Advisors License License Research Projects Organizational Units Journal Issue Embargo Lift Date URI https://hdl.handle.net/20.500.14394/8325 DOI Publisher Version Embedded videos Collections Communication Disorders Department Faculty Publication Series Related Item(s) Show all metadata Show statistical information

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Condition tags

endometriosis

MeSH descriptors

Danazol Endometriosis Phonation Pregnadienes Vibration Vibration Vocal Cords Voice Adult Adult Danazol Danazol Endometriosis Endometriosis Female Female Humans Humans Phonation Phonation

Citation neighborhood (sparse)

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Cited by (3)

Cited by (3)

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