Protective effects of apigenin on LPS-induced endometritis via activating Nrf2 signaling pathway

Pei-Yue Jiang, Peiyue Jiang, Xiao-Jun Zhu, Xiaojun Zhu, Yina Zhang, Yi-Na Zhang, Fei-Fei Zhou, Feifei Zhou, Xiaofu Yang, Xiao-Fu Yang
Microbial pathogenesis · 2018 · vol. 123 , pp. 139–143 · doi:10.1016/j.micpath.2018.06.031 · PMID:29928944 · W2808929048
Lab / animal OA: closed CC0 ⤵ 3 in-corpus citations
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This study investigated apigenin's protective effects against LPS-induced endometritis and found that it activates the Nrf2 signaling pathway to achieve this protection.

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Abstract

Endometritis is a puzzling disease that often associates with severe pelvic pain. In this study, we aimed to detect whether apigenin had protective effect against LPS-induced endometritis, if so, the underlying mechanism was further investigated. Apigenin was administrated 1 h before LPS treatment. The levels of inflammatory cytokines were measured by ELISA. The expression of NF-κB and Nrf2 were detected by Western blot analysis. The results showed that LPS treatment induced severe histological alteration of uterus and this change was attenuated by the treatment of apigenin. Apigenin significantly attenuated LPS-induced MPO activity, MDA content, and inflammatory cytokines TNF-α and IL-1β production. LPS-induced NF-κB activation was suppressed by apigenin. Furthermore, apigenin elevated the expression of Nrf2 and HO-1 in uterine tissues. In conclusion, the present study demonstrated that apigenin protected against LPS-induced endometritis through activation of Nrf2 signaling pathway and inhibition of NF-κB signaling pathway.

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Condition tags

disambig:endometritis

MeSH descriptors

Apigenin Endometritis Lipopolysaccharides NF-E2-Related Factor 2 Protective Agents Signal Transduction Animals Apigenin Apigenin Cytokines Cytokines Endometritis Endometritis Female Heme Oxygenase-1 Heme Oxygenase-1 Interleukin-1beta Interleukin-1beta Lipopolysaccharides Membrane Proteins

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