Uterine artery Doppler and endometrial blood flow in frozen embryo transfer: A cohort study.

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This cohort study evaluated the predictive value of uterine artery Doppler indices and endometrial perfusion zones for clinical pregnancy outcomes in 250 women undergoing frozen embryo transfer. The researchers found that while peak systolic velocity and resistance index showed no significant difference between groups, a higher pulsatility index was associated with negative pregnancy outcomes. Furthermore, adequate endometrial blood flow in deeper zones significantly reduced the risk of failed implantation compared to superficial zone perfusion alone. This paper is not centrally about endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

BackgroundThe implantation rate after assisted reproductive technology depends on 2 important factors, good quality embryo and endometrial receptivity. Endometrial receptivity is mainly assessed by ultrasound measurement of endometrial thickness and morphology.ObjectiveThis study aimed to investigate the relationship between uterine artery Doppler indices/endometrial perfusion and pregnancy rate.Materials and methodsThis cohort study was done on 250 women who were candidates for frozen embryo transfer from January to July 2022. For assessing endometrial receptivity, we performed a Doppler ultrasound of the uterus before embryo transfer with apparently desirable endometrium (endometrial thickness ≥ 7 mm and 3 line endometrial pattern). In addition, the women were divided into 2 groups according to assisted reproductive technology outcome (clinical pregnancy), group I positive clinical pregnancy, and group II negative clinical pregnancy, and uterine artery indices and endometrial perfusion were compared between these groups.ResultsUterine artery Doppler showed that the pulsatility index was significantly different between positive and negative clinical pregnancy groups, but resistance index and peak systolic velocity (PSV) did not have statistically significant differences. Also, endometrial perfusion was significantly different between the 2 groups of clinical pregnancy. Endometrial perfusion was significantly better in positive clinical pregnancy groups.ConclusionDoppler ultrasound can help to assess endometrial receptivity.
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Section

Endometrial perfusion in zones II and III improves the pregnancy rate. It appears that the combined measurements of uterine artery PI, endometrial perfusion, and ET can be good contributing factors for pregnancy rate. Furthermore, our findings align with the generally accepted notion that a good endometrial blood supply is required for successful implantation.

Coi Statement

The authors declare that there is no conflict of interest.

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europepmc
last seen: 2026-08-23T09:30:01.253652+00:00
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