Danazol-induced biochemical changes in the rat ovary

G K Sangha, Gurinder Kaur Sangha, Nagesh Chopra, N Chopra
Indian journal of physiology and pharmacology · 1998 · vol. 42(2) , pp. 252–8 · PMID:10225053 · W2474808080
Lab / animal OA: closed CC0 ⤵ 1 in-corpus citation
View on OpenAlex View on PubMed
⚙ AI-generated summary by qwen3.7-flash, 2026-08-26 ⓘ

Danazol treatment in rats decreased total proteins and phospholipids while increasing total lipids and triglycerides, with these biochemical alterations discussed in relation to ovarian follicular growth and atresia.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Effect of varying doses of danazol, a synthetic steroid derivative of 17 alpha-ethinyl testosterone has been observed on the biochemistry of the rat ovary. Biochemically total proteins decreased and total lipids increased with the danazol treatment. Triglycerides, the stored form of lipids formed the major components of lipids in the treated ovaries. The amount of phospholipids, glycolipids, cholesterol and free fatty acids decreased in the ovaries with increased danazol treatment. The functional significance of these changes have been discussed with ovarian physiology especially in relation to follicular growth and atresia.

My notes (saved in your browser only)

MeSH descriptors

Danazol Estrogen Antagonists Ovary Ovary Animals Danazol Dose-Response Relationship, Drug Estrogen Antagonists Fatty Acids, Nonesterified Fatty Acids, Nonesterified Female Glycolipids Glycolipids Injections, Subcutaneous Ovary Ovary Phospholipids Phospholipids Rats Rats, Wistar

Citation neighborhood (sparse)

Too few in-corpus citations on either side for a chart; here are the lists.

Cites (1)

Cited by (1)

References (8)

Cited by (1)

Source provenance

openalex
last seen: 2026-05-10T10:40:17.476207+00:00
pubmed
last seen: 2026-10-08T20:58:57.924351+00:00
License: CC0 · commercial use OK