Estrogen receptor β agonist inhibits proliferation of endometrial stromal cells in an estrogen-receptor independent manner

Qiong Xia, Dong Zhao, Juan Wang
In: Archives of Biological Sciences · 2014 · vol. 66(2) , pp. 735–741 · doi:10.2298/abs1402735x · W2057255926
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

Diarylpropionitrile, an ERβ agonist, inhibited human endometrial stromal cell proliferation independently of ERβ, despite ERβ expression being absent in endometrial stromal cells.

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Abstract

The finding that estrogen receptor ER? agonists induce regression of ectopic endometrial implants in a rodent model has rekindled interest in the role of ER? in the growth and maintenance of human endometriosis. We hypothesize that the ER? agonist may have a direct effect on the human endometrium. We examined the mRNA and protein expression of ER? in both eutopic and ectopic endometrium and performed a luciferase reporter assay for the presence of functional ER? in human endometrial stromal cells. Diarylpropionitrile (DPN - a ER? specific agonist) significantly inhibited endometrial stromal cell proliferation at 10 M by 25% but not at 10 nM. ER? mRNA is present in both eutopic and ectopic endometrium; however, protein expression is absent in both stroma and epithelium. Our search for functional ER? similarly showed an absence in endometrial stromal cells. These results suggest that the regression of endometriosis might be ER?-independent.

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endometriosis

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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