TO DETERMINE THE USE OF AN LNG-IUS FOR CONSERVATIVE MANAGEMENT IN WOMEN WITH SYMPTOMATIC MILD TO MODERATE ENDOMETRIOSIS

Kavita Chandnani, Rutwa Chavda
In: Journal of Evolution of Medical and Dental sciences · 2013 · vol. 2(28) , pp. 5223–5230 · doi:10.14260/jemds/974 · W2330729551
Non-randomised trial OA: bronze CC0
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This prospective study found that a levonorgestrel intrauterine system effectively relieved pain and menstrual symptoms and improved disease staging in women with symptomatic minimal to moderate endometriosis.

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Abstract

BACKGROUND: Medical treatment of endometriosis, a condition which significantly affects the quality of life in only 10–15% of women in the reproductive years, rest have no improvement. Although oral progestogens are effective and cheap, their efficacy is significantly influenced by poor compliance and systemic side effects. A progestogen (levonorgestrel) administered via an intrauterine system (Lng‐IUS) has been demonstrated to improve symptoms of endometriosis; however, its effect on the staging of the disease has not been evaluated. OBJECTIVE: The aims of this study were therefore to investigate the effectiveness of Lng‐IUS in the symptomatic relief of minimal to moderate endometriosis and in the staging of the disease. METHODS: This was a prospective non‐comparative observational study in which 33 women with clinically suspected and also confirmed by laparoscopically symptomatic minimal to moderate endometriosis had Lng‐IUS inserted for 6 months. The symptom profile and stage of the disease before, during and after 6 months of treatment and patients’ satisfaction with treatment and willingness to retain the device at the end of the study period were used to assess response to treatment. RESULTS: Out of the 33 women recruited, 29 (87%) completed the study; four discontinued. Rest 29 patients had significant improvements in severity and frequency of pain and menstrual symptoms as well as staging were achieved, and elected to continue with the device after 6 months of therapy. CONCLUSION: The levonorgestrel intrauterine system is an effective hormonal option for treating symptomatic endometriosis (minimal to moderate). It has the potential for providing long‐term therapy in a substantial number of sufferers, although this would require further study and verification.

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Condition tags

endometriosis

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (24)

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