Use of CA-125 in the diagnosis and management of endometriosis: influence of treatment with danazol

Ioannis Matalliotakis, I Matalliotakis, Matalliotakis I, A Makrigiannakis, Antonis Makrigiannakis, Makrigiannakis A, Karkavitsas N, N Karkavitsas, Psaroudakis E, E Psaroudakis, G Froudarakis, Froudarakis G, Koumantakis E, E Koumantakis
International journal of fertility and menopausal studies · 1994 · vol. 39(2) , pp. 100–4 · PMID:8012438 · W2416275443
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CA-125 levels were significantly higher in women with endometriosis compared to controls, and danazol treatment significantly reduced these levels, supporting its use in diagnosis and management.

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Abstract

OBJECTIVE: To compare CA-125 levels in endometriotic women with normal controls. PATIENTS AND METHODS: The level of the oncofetal antigen CA-125 was measured in serum samples taken from 40 women, aged 21 to 33 years. Blood samples for CA-125 from 15 endometriotic women were measured before treatment, during the last 15 days of a 6-month administration of Danazol, and 3 months after treatment, and were compared to findings in 15 women without endometriosis (from whom blood samples were taken only once). RESULTS: The CA-125 levels were significantly higher in patients with endometriosis before treatment as compared with the controls (P < .01). The administration of Danazol significantly reduced the levels of CA-125 (P < .01), and 3 months after treatment the levels of CA-125 remained significantly lower (P < .05) as compared to the respective pretreatment values. CONCLUSION: The results support the view that the determination of CA-125 levels may assist in (a) evaluating women with endometriosis and (b) treatment with Danazol.

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Condition tags

endometriosis

MeSH descriptors

Antigens, Tumor-Associated, Carbohydrate Endometriosis Endometriosis Adult Adult Antigens, Tumor-Associated, Carbohydrate Antigens, Tumor-Associated, Carbohydrate Endometriosis Endometriosis Endometriosis Evaluation Studies as Topic Evaluation Studies as Topic Female Female Humans Humans

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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