Use of CA-125 in the diagnosis and management of endometriosis: influence of treatment with danazol.

I Matalliotakis, Ioannis Matalliotakis, Antonis Makrigiannakis, A Makrigiannakis, N Karkavitsas, E Psaroudakis, G Froudarakis, E Koumantakis
International journal of fertility and menopausal studies · 1994 · vol. 39(2) , pp. 100–4 · PMID:8012438 · W2416275443
article OA: closed CC0 ⤵ 5 in-corpus citations
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CA-125 levels were significantly higher in women with endometriosis compared to controls, and danazol treatment significantly reduced these levels, supporting its use in diagnosis and management.

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Abstract

OBJECTIVE: To compare CA-125 levels in endometriotic women with normal controls. PATIENTS AND METHODS: The level of the oncofetal antigen CA-125 was measured in serum samples taken from 40 women, aged 21 to 33 years. Blood samples for CA-125 from 15 endometriotic women were measured before treatment, during the last 15 days of a 6-month administration of Danazol, and 3 months after treatment, and were compared to findings in 15 women without endometriosis (from whom blood samples were taken only once). RESULTS: The CA-125 levels were significantly higher in patients with endometriosis before treatment as compared with the controls (P < .01). The administration of Danazol significantly reduced the levels of CA-125 (P < .01), and 3 months after treatment the levels of CA-125 remained significantly lower (P < .05) as compared to the respective pretreatment values. CONCLUSION: The results support the view that the determination of CA-125 levels may assist in (a) evaluating women with endometriosis and (b) treatment with Danazol.

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Condition tags

endometriosis

MeSH descriptors

Antigens, Tumor-Associated, Carbohydrate Endometriosis Endometriosis Adult Antigens, Tumor-Associated, Carbohydrate Endometriosis Endometriosis Evaluation Studies as Topic Female Humans

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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License: CC0 · commercial use OK