Evaluation of the Release Rate of Gossypol Acetate from a Gossypol-Loaded Intrauterine Device in Mice
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This study demonstrated that a gossypol-loaded IUD in mice provided a sustained release of gossypol acetate into the plasma, reaching a peak on day two and remaining stable for months.
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Abstract
OBJECTIVE To explore the release rate of gossypol acetate from a designed gossypol-loaded intrauterine device(IUD) in mice.METHODS The mice were administrated with gossypol acetate-loaded IUD and then the release rate of gossypol acetate from the IUD was tested by HPLC.RESULTS The results showed that the concentration of plasma gossypol acetate gradually increased to a peak level of 0.30 μg-L-1 on the second day,which was then maintained for several months.CONCLUSION A gossypol-loaded IUD is a reliable method of administration for gossypol acetate and it is possibly an effective way to treat adenomyosis in mice.
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