Gossypol inhibits proliferation of endometrioma cells in culture

Shawky Z A Badawy, Badawy Sz, Souid AK, Abdul‐Kader Souid, Abdul-Kader Souid, Violeta Cuenca, Cuenca V, Nicholas Montalto, Montalto N, Shue F, Frances Shue
Asian journal of andrology · 2007 · vol. 9(3) , pp. 388–393 · doi:10.1111/j.1745-7262.2007.00168.x · PMID:17486280 · W2043581026
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Gossypol inhibited endometrioma cell proliferation and mitochondrial respiration in cultured cells.

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The paper evaluated whether gossypol has anti-proliferative activity and mitochondrial toxicity in short-term cultures of endometrioma cells. Using three patient-derived endometrioma cell lines, cells were treated with 25 or 50 nmol/L gossypol for up to 12 days and cell growth was measured, while mitochondrial oxygen consumption was assessed in six patient-derived lines using a phosphorescence oxygen analyzer and cellular gossypol accumulation was measured by high-performance liquid chromatography. Gossypol inhibited endometrioma cell proliferation at 25 and 50 nmol/L and impaired respiration, with mitochondrial oxygen consumption inhibited by 10 mol/L gossypol; treated cells also accumulated gossypol after 24 hours. A key limitation is that the study was performed in short-term in vitro cultures rather than in vivo. This paper is centrally about endometriosis — it tests gossypol’s effects on cultured endometrioma cells, focusing on proliferation inhibition and mitochondrial toxicity.

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Abstract

AIM: To evaluate the anti-proliferative activity and mitochondrial toxicity of gossypol in endometrioma cells maintained in short-term cultures. METHODS: (A) Three endometrioma cell lines from patients were treated with 25 or 50 nmol/L gossypol for up to 12 days. The effect of gossypol on the cell growth was recorded. (B) A phosphorescence oxygen analyzer was used to determine the effects of gossypol on mitochondrial oxygen consumption of six endometrioma cell lines from patients. (C) Cellular gossypol accumulations in three endometrioma cell lines from patients were measured by high-pressure liquid chromatography. RESULTS: Proliferation of the endometrioma cells was inhibited by 25 and 50 nmol/L gossypol. Respiration of the endometrioma cells was inhibited by 10 micromol/L gossypol. Cellular gossypol was detected in the endometrioma cell lines that were treated for 24 h with 10 and 0.3 micromol/L gossypol. CONCLUSION: Gossypol invokes a potent toxicity on cultured endometrioma cells.
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Methods

(A) Three endometrioma cell lines from patients were treated with 25 or 50 nmol/L gossypol for up to 12 days. The effect of gossypol on the cell growth was recorded. (B) A phosphorescence oxygen analyzer was used to determine the effects of gossypol on mitochondrial oxygen consumption of six endometrioma cell lines from patients. (C) Cellular gossypol accumulations in three endometrioma cell lines from patients were measured by high-pressure liquid chromatography.

Results

Proliferation of the endometrioma cells was inhibited by 25 and 50 nmol/L gossypol. Respiration of the endometrioma cells was inhibited by 10 mol/L gossypol. Cellular gossypol was detected in the endometrioma cell lines that were treated for 24 h with 10 and 0.3 mol/L gossypol.

Conclusion

Gossypol invokes a potent toxicity on cultured endometrioma cells.

Keywords

gossypol, endometrioma, mitochondria, oxygen consumption, cellular respiration Full Text | PDF | 中文摘要 | | | | | Browse: 4018 | |

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Condition tags

endometriosisendometrioma

MeSH descriptors

Contraceptive Agents, Male Endometrial Neoplasms Endometriosis Gossypol Cell Line, Tumor Cell Proliferation Cell Proliferation Cell Respiration Cell Respiration Cell Respiration Cell Survival Cell Survival Contraceptive Agents, Male Cottonseed Oil Cottonseed Oil Dose-Response Relationship, Drug Endometrial Neoplasms Endometrial Neoplasms Endometriosis Endometriosis

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