Changes of CD19 + CD5 + B cells and BAFF in endometriosis

Yanping Jiang, Ruoyu Luo
In: 中国医师杂志 · 2010 · vol. 12(11) , pp. 1467–1470 · doi:10.3760/cma.j.issn.1008-1372.2010.11.010 · W3032626687
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Endometriosis patients exhibited increased frequencies of CD19+CD5+B cells in peripheral blood, peritoneal fluid, and endometrium alongside elevated BAFF expression and resistance to apoptosis compared to controls.

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This study investigated the role of CD19+CD5+B cells in endometriosis by comparing 39 patients with the disease to 31 controls with uterine myomas. Researchers utilized flow cytometry and quantitative PCR to analyze these B cells in peripheral blood, peritoneal fluid, and endometrial tissue samples. The results showed that endometriosis patients had significantly higher frequencies of these specific B cells, which also exhibited increased BAFF mRNA expression and greater resistance to apoptosis induced by CD95L compared to the control group. This paper is centrally about endometriosis — specifically examining the immunological mechanisms involving autoreactive B cells and their survival signals in the disease's pathogenesis.

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Abstract

Objective To explore the changes of frequency, BAFF expression and sensitivity to apoptosis of CD19 + CD5 + B cells in endometriosis patients and investigate the relationship between CD19 +CD5 + B cells and endometriosis. Methods Flow cytometry and quantitative PCR were used to assess the frequency, BAFF expression and sensitivity to apoptosis of CD19+ CD5 + B cells in the peripheral blood,peritoneal fluids and endometrium biopsies of 39 patients with endometriosis and 31 patients with myoma of uterus ( control subjects). Results: All 39 endometriosis patients had higher frequencies ( all P ＜ 0. 01 ) of CD19 + CD5 + B cells in the peripheral blood, peritoneal fluids and endometrium biopsies than that in 31 control subjects. CD19 + CD5 + B cells from endometriosis patients expressed higher BAFF, and were more resistant to CD95L-induced apoptosis than the cells from control subjects ( P ＜ 0. 01 ). Conclusion CD19 + CD5 + B cells might play an important role in the pathogenesis of endometriosis through higher BAFF expression and more resistance to CD95L-induced apoptosis. Key words: Endometriosis/ME/IM;  B-lymphocytes/ME;  Antigens, CD19/ME;  Antigens, CD5/ME;  B-cell activating factor/ME
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摘要目的 了解子宫内膜异位症患者中CD19+CD5+B细胞的变化,CD19+CD5+B细胞中BAFF(B淋巴细胞刺激因子)的表达和凋亡敏感性变化,探讨CD19+CD5+B细胞与子宫内膜异位症的关系.方法 39例子宫内膜异位症患者为实验组,31例子宫肌瘤患者为对照组,流式细胞术检测患者外周血、腹腔冲洗液以及子宫内膜组织中CD19+CD5+B细胞的变化,Q-PCR检测CD19+CD5+B细胞中BAFF mRNA的表达,流式细胞术PI-Annexin V检测CD19+CD5+B细胞对CD95L诱导的凋亡敏感性.结果 实验组患者外周血、腹腔冲洗液以及异位子宫内膜组织中CD19+CD5+B细胞高于对照组(P＜0.01);实验组患者各样本中CD19+CD5+B细胞的BAFF mRNA表达水平高于对照组,CD19+CD5+B细胞能明显抵抗CD95L所诱导的凋亡(P＜0.01).结论 在子宫内膜异位症中,CD19+CD5+B细胞高表达BAFF,高对抗CD95L诱导的凋亡,参与疾病的发生. 更多相关知识 abstractsObjective To explore the changes of frequency, BAFF expression and sensitivity to apoptosis of CD19 + CD5 + B cells in endometriosis patients and investigate the relationship between CD19 +CD5 + B cells and endometriosis. Methods Flow cytometry and quantitative PCR were used to assess the frequency, BAFF expression and sensitivity to apoptosis of CD19+ CD5 + B cells in the peripheral blood,peritoneal fluids and endometrium biopsies of 39 patients with endometriosis and 31 patients with myoma of uterus ( control subjects). Results: All 39 endometriosis patients had higher frequencies ( all P ＜ 0. 01 ) of CD19 + CD5 + B cells in the peripheral blood, peritoneal fluids and endometrium biopsies than that in 31 control subjects. CD19 + CD5 + B cells from endometriosis patients expressed higher BAFF, and were more resistant to CD95L-induced apoptosis than the cells from control subjects ( P ＜ 0. 01 ). Conclusion CD19 + CD5 + B cells might play an important role in the pathogenesis of endometriosis through higher BAFF expression and more resistance to CD95L-induced apoptosis. More相关知识 - 浏览386 - 被引0 - 下载16 相似文献 - 中文期刊 - 外文期刊 - 学位论文 - 会议论文

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