Endometriosis and chronic intestinal diseases: is there a relationship? (Literature review)

Victoria A. Pechenikova, Nikol N. Petrovskaia, Е. А. Семенова, Anastasia D. Korchinskaya, Kristina V. Nikiforova
In: Journal of Volgograd State Medical University · 2025 · vol. 22(1) , pp. 16–27 · doi:10.19163/1994-9480-2025-22-1-16-27 · W4411126875
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⚙ AI-generated summary by claude@2026-06, 2026-06-06 ⓘ

This literature review analyzed the relationship between endometriosis and gastrointestinal diseases, finding that these conditions can coexist and require multidisciplinary examination and treatment.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-06 ⓘ

This 2025 literature review analyzes and systematizes published data on the relationship between genital endometriosis and gastrointestinal tract diseases, focusing on comorbidity patterns and contradictions in the literature. It describes overlapping clinical presentations between endometriosis involving the bowel (reported in a minority of genital endometriosis cases, with common involvement of the rectosigmoid) and chronic GI disorders such as irritable bowel syndrome, celiac disease, and inflammatory bowel diseases (Crohn’s disease and ulcerative colitis), including shared symptom domains and differences in timing and features; it also notes that most intestinal involvement is thought to be secondary to spread from other sites, while primary intestinal disease is rare. The review explicitly highlights that the evidence includes existing discrepancies and that further clarification is needed. Relevance to endometriosis: This paper is centrally about endometriosis — it specifically reviews potential links between genital endometriosis and chronic intestinal diseases (IBS, celiac disease, Crohn’s disease, ulcerative colitis) and their combined clinical course.

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Abstract

Relevance: Endometriosis and irritable bowel syndrome are two pathologies affecting a significant part of the female population, together or separately, with serious consequences for the quality of life. Patients with endometriosis and gastrointestinal symptoms can have clinical manifestations which can be connected with a variety of gastrointestinal diseases, such as inflammatory bowel diseases (Crohn’s disease and ulcerative colitis), celiac disease and irritable bowel syndrome. The purpose of the study: To analyze and systematize the literature data on the relationship between genital endometriosis and gastrointestinal tract disease. The results of the study: The analysis and systematization of literature data on the comorbidity of endometriosis and gastrointestinal tract diseases, taking into account the existing contradictions about the relationship and features of the combined course of these pathologies, requiring further clarification. Conclusion: In some cases, patients with genital endometriosis and/or chronic inflammatory diseases of the gastrointestinal tract should be jointly examined and treated by a gastroenterologist and gynecologist.

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Condition tags

endometriosisirritable_bowel_syndrome

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (55)

Source provenance

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last seen: 2026-06-10T17:14:06.276822+00:00
License: CC0 · commercial use OK