Pseudotumour cerebri and carpal tunnel syndrome associated with danazol therapy

Udo K. Schmitz, Claudia Honisch, Stephan Zierz
In: Journal of Neurology · 1991 · vol. 238(6) , pp. 355 · doi:10.1007/bf00315339 · PMID:1940991 · W2061632596
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-12 ⓘ

This paper reviews cases of pseudotumor cerebri and carpal tunnel syndrome observed in patients undergoing danazol therapy.

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This paper reports on pseudotumour cerebri and carpal tunnel syndrome occurring in association with danazol therapy, describing clinical observations that link the medication to both intracranial hypertension–type manifestations and peripheral nerve symptoms. The authors present the association at a case/report level, without providing a study population in the excerpted text, and the main limitation is that the paper’s evidence base is observational rather than demonstrating mechanism or incidence. This paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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References Donaldson JO (1981) Pathogenesis of pseudotumor cerebri syndromes. Neurology 31:877–880 Gray RG (1978) Bilateral carpal tunnel syndrome and arthritis associated with danazol administration. Arthritis Rheum 21:493–494 Hamed LM, Glaser JS, Schatz NJ, Perez TH (1989) Pseudotumor cerebri induced by danazol. Am J Ophtalmol 107:105–110 Mann JD, Johnson RN, Butler AB, Bass NH (1979) Impairment of cerbrospinal fluid circulatory dynamics in pseudotumor cerebri and response to steroid treatment, abstracted. Neurology 29:550 Pears J, Sandercock PA (1990) Benign intracranial hypertension associated with danazol. Scott Med J 35:49 Raichle ME, Grubb RL Jr, Phelps ME, Gado MH, Caronna JJ (1978) Cerebral hemodynamics and metabolism in pseudotumor cerebri. Ann Neurol 4:104–111 Rakoff AE (1976) Side effects of danazol therapy. In: Greenblatt RB (ed) Recent advances in endometriosis. Proceedings of the Symposium, Augusta 1975. Excerpta Medica, Amsterdam, pp 108–115 Shah A, Roberts I, McQueen INF, Graham JG, Walker K (1987) Danazol and benign intracranial hypertension. BMT 294:1323 Sikka A, Kemmann E, Vrablik RM, Grossman L (1983) Carpal tunnel syndrome associated with danazol therapy. Am J Obstet Gynecol 147:102–103 Author information Authors and Affiliations Rights and permissions About this article Cite this article Schmitz, U., Honisch, C. & Zierz, S. Pseudotumour cerebri and carpal tunnel syndrome associated with danazol therapy. J Neurol 238, 355 (1991). https://doi.org/10.1007/BF00315339 Received: Accepted: Issue date: DOI: https://doi.org/10.1007/BF00315339

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